Effects of Strength Training on Upper-Limb Function in Post-Stroke Hemiparesis
NCT ID: NCT00037908
Last Updated: 2009-01-21
Study Results
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Basic Information
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COMPLETED
PHASE2
60 participants
INTERVENTIONAL
2000-10-31
2003-09-30
Brief Summary
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Detailed Description
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1. a) Standard functional rehabilitation combined with strength training in the form of high-intensity resistance exercise results in greater gains in elbow and shoulder strength than standard functional rehabilitation alone.
b) This increased strength is not accompanied by increased hypertonia. c) This increased strength is not accompanied by significant muscular hypertrophy.
2. Standard functional rehabilitation combined with strength training results in greater improvements in motor function than functional rehabilitation alone.
3. Strength training results in improved control of elbow trajectory tracking movements and shoulder-elbow reaching movements.
Specific Objectives
1. To perform a controlled, randomized, double-blind clinical trial to test the effects of high-intensity resistance exercise at the shoulder and elbow. Two interventions will be compared: standard functional rehabilitation (SFR), and standard functional rehabilitation combined with high-intensity resistance exercise (strength training) (SFR+STR). We will study persons with post-stroke hemiparesis in the subacute phase of recovery, i.e. having completed all outpatient therapy programs, but still less than 6 months post-CVA. Outcome measures will include strength (maximal voluntary isovelocity joint torque), hypertonia (onset threshold of the stretch reflex, Modified Ashworth Scale), standard clinical assessment of activities of daily living (Barthel Index, Functional Independence Measure), and upper extremity motor function (Fugl-Meyer exam, Functional Test of the Hemiparetic Upper Extremity).
2. To study the neuromuscular mechanisms associated with improvements in strength and motor control that result from these interventions. Strength changes will be investigated by measuring muscle hypertrophy, hyperreflexia, and passive stiffness. Changes in control of upper extremity movements will be investigated by measuring motor performance and muscle activation patterns in trajectory tracking and reaching tasks.
Our long term goal is to develop therapeutic interventions to improve upper-limb motor function in persons with post-stroke hemiparesis. Improved motor function involves not only increased strength at the shoulder and elbow, but also increased strength and dexterity at the wrist and hand. The proposed study will establish a foundation by demonstrating the positive effects of strength training in persons with hemiparesis. Then, in future studies, we can investigate the effects of specific interventions at the hand and wrist and investigate physiologic mechanisms subserving change in neuromuscular function following strength training.
Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
TREATMENT
DOUBLE
Interventions
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Strength training
Eligibility Criteria
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Inclusion Criteria
18 Years
ALL
No
Sponsors
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US Department of Veterans Affairs
FED
Principal Investigators
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David Wolff, Ph.D. Special Assistant to the Director
Role:
Program Analysis and Review Section (PARS) VA Rehabilitation Research & Development Service
Danielle M Kerkovitch, Ph.D.
Role:
Program Analysis and Review Section (PARS), VA Rehabilitation Research and Development Service
Locations
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VAMC
Palo Alto, California, United States
Countries
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Other Identifiers
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B2405R
Identifier Type: -
Identifier Source: org_study_id
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