Continuous Regional Arterial Infusion of Low Molecular Weight Heparin in Patients With Severe Acute Pancreatitis
NCT ID: NCT01626911
Last Updated: 2013-12-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
60 participants
INTERVENTIONAL
2011-09-30
Brief Summary
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In this study, the investigators aim to evaluate the effects of CRAI of LMWH in the treatment of SAP patients. The investigators suppose CRAI could help improve the outcomes of these patients.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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CRAI
CRAI of LMWH in the celiac trunk
Continuous regional arterial infusion of low molecular weight heparin in celiac trunk
Put a catheter to the celiac trunk through interventional technique. The approach to celiac trunk was via a femoral artery approach.The tip of the arterial catheter (4F) was placed in celiac trunk which could perfuse the pancreas.After that, continuous infusion of low molecular weight heparin through the catheter will be applied during the first 5 days after placement.
General treatment
Include fluid resuscitation, percutaneous drainage if needed, antibiotics,organ support, etc.
Conservative treatment
Conservative treatment without CRAI, control group
General treatment
Include fluid resuscitation, percutaneous drainage if needed, antibiotics,organ support, etc.
Interventions
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Continuous regional arterial infusion of low molecular weight heparin in celiac trunk
Put a catheter to the celiac trunk through interventional technique. The approach to celiac trunk was via a femoral artery approach.The tip of the arterial catheter (4F) was placed in celiac trunk which could perfuse the pancreas.After that, continuous infusion of low molecular weight heparin through the catheter will be applied during the first 5 days after placement.
General treatment
Include fluid resuscitation, percutaneous drainage if needed, antibiotics,organ support, etc.
Eligibility Criteria
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Inclusion Criteria
* Within 3 days from the onset of the disease
* Available for interventional treatment(not sensible to radiocontrast agent)
Exclusion Criteria
* Receiving surgery or aspiration before;need of early surgery
* Patients with coagulation disorders
18 Years
70 Years
ALL
No
Sponsors
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Nanjing University School of Medicine
OTHER
Responsible Party
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Weiqin Li
Director of surgical ICU
Principal Investigators
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Weiqin Li, Dr
Role: PRINCIPAL_INVESTIGATOR
Jinling Hospital, School of Medicine, Nanjing University
Locations
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Department of SICU, Research Institute of General Surgery Jinling Hospital, Nanjing, Jiangsu, China
Nanjing, Jiangsu, China
Countries
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Central Contacts
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Facility Contacts
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Weiqin Li, Dr
Role: primary
References
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Lu XS, Qiu F, Li YX, Li JQ, Fan QQ, Zhou RG. Effect of lower-molecular weight heparin in the prevention of pancreatic encephalopathy in the patient with severe acute pancreatitis. Pancreas. 2010 May;39(4):516-9. doi: 10.1097/MPA.0b013e3181c3c954.
Other Identifiers
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CRAI-H
Identifier Type: -
Identifier Source: org_study_id