Role of Amlodipine in Reduction of CIN

NCT ID: NCT07291375

Last Updated: 2025-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

EARLY_PHASE1

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-20

Study Completion Date

2026-07-01

Brief Summary

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The aim is to assess the benefit of low dose oral amlodipine in renal protection from contrast induced nephropathy in diabetic patients in intensive care unit

Detailed Description

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Conditions

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Contrast-induced Nephropathy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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Control group

this group who undergoing iv contrast will receive hydration only

Group Type OTHER

Hydration

Intervention Type OTHER

before the procedure patients will recieve iv bolus of 250 ml saline followed by continous infusion of 100 ml/h of normal saline

Amlodipine group

this group will receive hydration and amlodipine

Group Type OTHER

Calcium channel blocker

Intervention Type DRUG

amlodipine group will receive low dose oral amlodipine ( 5 mg ) before iv contrast and every 12 hour for 48 hour

Hydration

Intervention Type OTHER

before the procedure patients will recieve iv bolus of 250 ml saline followed by continous infusion of 100 ml/h of normal saline

Interventions

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Calcium channel blocker

amlodipine group will receive low dose oral amlodipine ( 5 mg ) before iv contrast and every 12 hour for 48 hour

Intervention Type DRUG

Hydration

before the procedure patients will recieve iv bolus of 250 ml saline followed by continous infusion of 100 ml/h of normal saline

Intervention Type OTHER

Other Intervention Names

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amlodipine ( 5mg)

Eligibility Criteria

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Inclusion Criteria

* adult patients of both sexes (18:70) diabetic patients with serum creatinine below 1.2 hemodynamically stable patients ASA physical status 2,3

Exclusion Criteria

* patient refusal patients of chronic kidney diseases NPO patients serum creatinine above 1.2 Hypertensive patients
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Minia University

OTHER

Sponsor Role lead

Responsible Party

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Andrew Samy Shafeek Shehata

Andrew Samy Shafeek

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Andrew Shehata, Master

Role: CONTACT

Phone: 0201067820073

Email: [email protected]

Other Identifiers

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Amlodipine role in CIN

Identifier Type: -

Identifier Source: org_study_id