Sleep Related Breathing Disturbances and High Altitude Pulmonary Hypertension in Kyrgyz Highlanders

NCT ID: NCT01621061

Last Updated: 2014-05-15

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 125 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2012-06-30
• Study Completion Date: 2013-12-31

Brief Summary

High altitude pulmonary hypertension, a form of altitude illness that occurs in long-term residents at altitudes >2500 m, is characterized by dyspnea, hypoxemia, impaired exercise performance and hypertension in the pulmonary circulation. Whether sleep related breathing disturbances, common causes of nocturnal hypoxemia in lowlanders, are also prevalent in highlanders and promote pulmonary hypertension in highlanders is unknown. Therefore, the current study will investigate whether highlanders with high altitude pulmonary hypertension have a greater prevalence of sleep apnea than healthy highlanders and lowlanders.

Conditions

High Altitude Pulmonary Hypertension; Sleep Apnea

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

High altitude pulmonary hypertension

Highlanders with high altitude pulmonary hypertension

No interventions assigned to this group

High altitude control

Healthy highlanders

No interventions assigned to this group

Low altitude control

Healthy lowlanders

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• high altitude pulmonary hypertension confirmed by clinical presentation and systolic pulmonary artery pressure >50 mmHg measured by echocardiography at altitude of residence.
• healthy subjects (high altitude controls)
• Both genders
• Age >16 y
• Kyrgyz ethnicity
• born, raised and currently living at >2500 m
• healthy subjects currently living at <1000 m (low altitude controls)

Exclusion Criteria

• Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography
• excessive erythrocytosis
• other coexistent disorders that may interfere with the cardio-respiratory system and sleep
• regular use of medication that affects control of breathing
• heavy smoking

• Minimum Eligible Age: 16 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov

OTHER_GOV

Sponsor Role: collaborator

University of Zurich

OTHER

Sponsor Role: lead

Responsible Party

Konrad E. Bloch

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Konrad E Bloch, MD

Role: PRINCIPAL_INVESTIGATOR

University of Zurich, Switzerland

Talant Sooronbaev, MD

Role: PRINCIPAL_INVESTIGATOR

National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov

Locations

National Center for Cardiology and Internal Medicine

Bishkek, , Kyrgyzstan

Countries

Kyrgyzstan

Other Identifiers

01-7/219

Identifier Type: -

Identifier Source: org_study_id