Nocturnal Oxygenation and Sleep-related Breathing Disorders During the First Night of a Stay at 2500m of High Altitude in Patients With Precapillary Pulmonary Hypertension
NCT ID: NCT05089487
Last Updated: 2022-05-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
28 participants
INTERVENTIONAL
2021-10-18
2022-04-15
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
SCREENING
NONE
Study Groups
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High altitude 2500 m above sea level
Nocturnal rest (sleep study)
Proportion of patients free of severe hypoxemia without oxygen therapy during nocturnal rest .
Low altitude 470 m above sea level
Nocturnal rest (sleep study)
Proportion of patients free of severe hypoxemia without oxygen therapy during nocturnal rest .
Interventions
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Nocturnal rest (sleep study)
Proportion of patients free of severe hypoxemia without oxygen therapy during nocturnal rest .
Eligibility Criteria
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Inclusion Criteria
* PH class I (PAH) or IV (CTEPH) diagnosed according to guidelines: mean pulmonary artery pressure \>20 mmHg, pulmonary vascular resistance ≥3 wood units, pulmonary arterial wedge pressure ≤15 mmHg during baseline measures at the diagnostic right-heart catheterization
Exclusion Criteria
* exposure to an altitude \>1000 m for ≥3 nights during the last 2 weeks before the study
* inability to follow the procedures of the study
* other clinically significant concomitant end-stage disease (e.g., renal failure, hepatic dysfunction)
18 Years
ALL
No
Sponsors
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University of Zurich
OTHER
Responsible Party
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Locations
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University Hospital of Zurich
Zurich, , Switzerland
Countries
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References
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Lichtblau M, Schwarz EI, Ulrich T, Schneider SR, Bauer M, Furian M, Carta A, Forrer A, Saxer S, Muller J, Preiss H, Mayer L, Bloch KE, Ulrich S. Effect of an Overnight Stay at 2,500 Meters on Nocturnal Hypoxemia and Sleep-disordered Breathing in Patients with Pulmonary Vascular Disease: A Randomized Clinical Trial. Ann Am Thorac Soc. 2025 Jul;22(7):1053-1061. doi: 10.1513/AnnalsATS.202412-1279OC.
Other Identifiers
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OVERALP II E
Identifier Type: -
Identifier Source: org_study_id
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