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Valsalva Manœuvre in the Diagnosis of Left Ventricular Failure in Chronic Obstructive Pulmonary Disease Exacerbation

NCT ID: NCT01619540

Last Updated: 2013-09-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-05-31

Study Completion Date

2013-06-30

Brief Summary

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Left ventricular failure (LVF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

This association is frequently underestimated with regard to the difficulty of clinical diagnosis .

The investigators expect that Valsalva Maneuver (VM) could be useful in this issue.

Detailed Description

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Conditions

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Acute Heart Failure COPD Exacerbation

Keywords

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COPD Left Ventricular Failure Valsalva Manoeuver

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Investigators

Study Groups

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acute heart failure

control arm

Group Type OTHER

Valsalva maneuver

Intervention Type OTHER

COPD exacerbation

COPD exacerbation

Group Type EXPERIMENTAL

Valsalva maneuver

Intervention Type OTHER

Interventions

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Valsalva maneuver

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* We included in this group, patients with a history (previous history) of COPD who consulted the emergency room for an exacerbation of COPD defined by a respiratory rate\> 25c/min and a pH \<7.35 and a PaCO2 \>6 KPa.
* This group is also divided into two groups according to clinical expert assessment and the BNP value: Group1 : BNP\> 400pg/ml, Group2 : BNP \<400PG / ml

Exclusion Criteria

* We excluded from this study patients with Prominent cardiac arrest
* Rhythm disorders including severe tachycardia arrhythmia
* Auricular fibrillation
* Hemodynamic instability requiring the use of vasoactive drugs and a contre indications of non invasive ventilation such us consciousness disorders with a Glasgow score \<12/15,a swallowing disorder
* A significant bronchial obstruction ,the upper airway obstruction , in upper gastrointestinal bleeding in progress, an extreme obesity and Cirrhosis or cancer.
* We are also excluded patients who did not cooperate and those who refused the study.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Monastir

OTHER

Sponsor Role lead

Responsible Party

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Nouira

Study of the Valsalva Manœuvre in Diagnoses of Left Ventricular Failure During Acute Exacerbation of Chronic Obstructive Pulmonary Desease

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Nouira Semir, Professor

Role: PRINCIPAL_INVESTIGATOR

Monastir University

Locations

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Fattouma Bourguiba University hospital

Monastir, Monastir Governorate, Tunisia

Site Status

University hospital of Moastir

Monastir, Monastir Governorate, Tunisia

Site Status

University hospital of Monastir

Monastir, Monastir Governorate, Tunisia

Site Status

University Hospital of Monastir

Monastir, Monstir, Tunisia

Site Status

Countries

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Tunisia

References

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Boubaker H, Grissa MH, Debbabi H, Beltaief K, Dridi Z, Najjar MF, Bouida W, Boukef R, Marghli S, Nouira S. Value of Plethysmographic Pulse Amplitude Ratio With Valsalva Maneuver in Identifying Left Ventricular Dysfunction During COPD Exacerbation. Respir Care. 2016 Apr;61(4):439-46. doi: 10.4187/respcare.04091. Epub 2015 Dec 8.

Reference Type DERIVED
PMID: 26647450 (View on PubMed)

Other Identifiers

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Valsalva

Identifier Type: -

Identifier Source: org_study_id