Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases

NCT ID: NCT04098094

Last Updated: 2022-02-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-09-19

Study Completion Date

2022-10-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Observational study in patients with chronic respiratory diseases (chronic obstructive pulmonary diseases, bronchiectasis, interstitial lung diseases, neuromuscular diseases, obesity-hypoventilation syndrome...) admitted in intensive care unit for acute respiratory failure. The main objective is to determine the prevalence of right ventricular (RV) dysfunction in this population and to analyze the impact of such a complication on outcomes (survival at day-28, duration of non-invasive or mechanical ventilation, duration of hospital stay). RV function will be assessed by echocardiography at admission, after 3 days and at discharge. Plasma NT-proBNP and troponin levels will be collected.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Observational study in patients with chronic respiratory diseases (chronic obstructive pulmonary diseases, bronchiectasis, interstitial lung diseases, neuromuscular diseases, obesity-hypoventilation syndrome...) admitted in intensive care unit for acute respiratory failure.

Inclusion Criteria:

* Chronic respiratory disease (COPD, ILD, OHS...)
* Admission in ICU for acute respiratory failure
* Patient's non-opposition

Exclusion Criteria:

* Patients \< 18 year-old
* Protected patients
* Pregnant women The main objective is to determine the prevalence of right ventricular (RV) dysfunction in this population and to analyze the impact of such a complication on outcomes (survival at day-28, duration of non-invasive or mechanical ventilation, duration of hospital stay). RV function will be assessed by echocardiography at admission, after 3 days and at discharge. Plasma NT-proBNP and troponin levels will be collected.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Exacerbation of COPD Acute Exacerbation of Bronchiectasis Acute Exacerbation of Asthma Interstitial Lung Disease Neuromuscular Diseases Obesity Hypoventilation Syndrome Acute Respiratory Failure

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Chronic respiratory disease (COPD, ILD, OHS...)
* Admission in ICU for acute respiratory failure
* Patient's non-opposition

Exclusion Criteria

* Patients \< 18 year-old
* Protected patients
* Pregnant women
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Alexandre Demoule, MD, PHD

Role: PRINCIPAL_INVESTIGATOR

Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Service de Pneumologie et Réanimation Médicale, Groupe Hospitalier Pitié Salpêtrière Paris, France

Paris, , France

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

France

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Athénaïs Boucly, MD

Role: CONTACT

+33669286528

Athénaïs Boucly, MD

Role: CONTACT

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Alexandre Demoule, MD, PhD

Role: primary

+33142167761

Athénaïs Boucly, MD

Role: backup

+33669286528

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2018-A03192-53

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.