Phenotypic Clinical, and Genetic Characteristics of Patients With Nontuberculosis Mycobacteria

NCT ID: NCT01616745

Last Updated: 2012-06-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-07-31

Study Completion Date

2021-02-28

Brief Summary

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The purpose of this study is to elucidate phenotypic, clinical, and genetic characteristics of Korean Nontuberculosis Mycobacteria (NTM) patients.

Detailed Description

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To elucidate phenotypic, clinical, and genetic characteristics of Korean NTM patients.

Especially, to compare body mass index, positive rate of IGRA, and CFTR mutation with general Korean population.

Conditions

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Nontuberculosis Mycobacterial Lung Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Persons met diagnostic criteria of NTM lung disease by ATS/IDSA on 2007

Exclusion Criteria

* Already on treatment for NTM lung disease
* Appropriate exclusion of other lung diagnosis
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jae-Joon Yim

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jae-Joon Yim, MD

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Hospital

Locations

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Seoul National University Hospital

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Jae-Joon Yim, MD

Role: CONTACT

82-2-2072-2059

Ae-Ra Lee, MD

Role: CONTACT

82-31-787-2455

Facility Contacts

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Jae-Joon Yim, MD

Role: primary

82-2-2072-2059

Ae-Ra Lee, MD

Role: backup

82-31-787-2455

References

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Hyung K, Kim SA, Kwak N, Yim JJ, Kim JY. Clinically significant hemoptysis and all-cause mortality in patients with nontuberculous mycobacterial pulmonary disease. Respir Med. 2025 Feb;237:107946. doi: 10.1016/j.rmed.2025.107946. Epub 2025 Jan 8.

Reference Type DERIVED
PMID: 39793860 (View on PubMed)

Hyung K, Kim SA, Kim JY, Kwak N, Yim JJ. Rates and Risk Factors of Progression in Patients With Nontuberculous Mycobacterial Pulmonary Disease: Secondary Analysis of a Prospective Cohort Study. Chest. 2024 Sep;166(3):452-460. doi: 10.1016/j.chest.2024.03.024. Epub 2024 Mar 16.

Reference Type DERIVED
PMID: 38499238 (View on PubMed)

Kwak N, Park J, Kim SJ, Kim JY, Kim TS, Yoon JK, Whang J, Lee W, Shin SJ, Yim JJ. Genetic stability of Mycobacterium abscessus during antibiotic treatment. J Glob Antimicrob Resist. 2024 Mar;36:45-49. doi: 10.1016/j.jgar.2023.12.004. Epub 2023 Dec 19.

Reference Type DERIVED
PMID: 38128724 (View on PubMed)

Jung HI, Kim SA, Kim HJ, Yim JJ, Kwak N. Anxiety and Depression in Patients With Nontuberculous Mycobacterial Pulmonary Disease: A Prospective Cohort Study in South Korea. Chest. 2022 Apr;161(4):918-926. doi: 10.1016/j.chest.2021.10.024. Epub 2021 Oct 28.

Reference Type DERIVED
PMID: 34756943 (View on PubMed)

Kwak N, Lee JH, Kim HJ, Kim SA, Yim JJ. New-onset nontuberculous mycobacterial pulmonary disease in bronchiectasis: tracking the clinical and radiographic changes. BMC Pulm Med. 2020 Nov 10;20(1):293. doi: 10.1186/s12890-020-01331-3.

Reference Type DERIVED
PMID: 33172424 (View on PubMed)

Kwak N, Whang J, Yang JS, Kim TS, Kim SA, Yim JJ. Minimal Inhibitory Concentration of Clofazimine Among Clinical Isolates of Nontuberculous Mycobacteria and Its Impact on Treatment Outcome. Chest. 2021 Feb;159(2):517-523. doi: 10.1016/j.chest.2020.07.040. Epub 2020 Jul 24.

Reference Type DERIVED
PMID: 32712225 (View on PubMed)

Kwak N, Kim SA, Choi SM, Lee J, Lee CH, Yim JJ. Longitudinal changes in health-related quality of life according to clinical course among patients with non-tuberculous mycobacterial pulmonary disease: a prospective cohort study. BMC Pulm Med. 2020 May 7;20(1):126. doi: 10.1186/s12890-020-1165-3.

Reference Type DERIVED
PMID: 32381080 (View on PubMed)

Kim HJ, Lee JH, Yoon SH, Kim SA, Kim MS, Choi SM, Lee J, Lee CH, Han SK, Yim JJ. Nontuberculous mycobacterial pulmonary disease diagnosed by two methods: a prospective cohort study. BMC Infect Dis. 2019 May 24;19(1):468. doi: 10.1186/s12879-019-4078-0.

Reference Type DERIVED
PMID: 31126235 (View on PubMed)

Kim SJ, Yoon SH, Choi SM, Lee J, Lee CH, Han SK, Yim JJ. Characteristics associated with progression in patients with of nontuberculous mycobacterial lung disease : a prospective cohort study. BMC Pulm Med. 2017 Jan 5;17(1):5. doi: 10.1186/s12890-016-0349-3.

Reference Type DERIVED
PMID: 28056937 (View on PubMed)

Lee AR, Lee J, Choi SM, Seong MW, Kim SA, Kim M, Chae KO, Lee JS, Yim JJ. Phenotypic, immunologic, and clinical characteristics of patients with nontuberculous mycobacterial lung disease in Korea. BMC Infect Dis. 2013 Nov 25;13:558. doi: 10.1186/1471-2334-13-558.

Reference Type DERIVED
PMID: 24274658 (View on PubMed)

Other Identifiers

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H-1103-057-355

Identifier Type: -

Identifier Source: org_study_id

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