Comparison of Genomic and Transcriptomic Patterns Between CTC and Metastatic Tumormetastatic Tumor

NCT ID: NCT04932343

Last Updated: 2021-06-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-06-01

Study Completion Date

2022-12-01

Brief Summary

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This study aims to understand the metastasis in advanced NSCLC through comparing genomic and transcriptomic patterns between the circulating tumor cells and metastatic tumor cells by single cell sequencing analysis.

Detailed Description

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Conditions

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NSCLC Stage IV NSCLC Stage IIIB

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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cohort study

no intervention

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* All subjects need to sign the informed consent form
* All subjects have non-small cell lung cancer which suspected on chest CT or confirmed pathologically preoperatively
* Treatment naïve advanced lung cancer (including extensive stage IIIb and stage IV)
* Patients who were suitable to provide enough metastatic tumor tissue and blood (30ml) for the single cells sequencing

Exclusion Criteria

* Patients with previous history of lung cancer
* Have been undergone chemotherapy or radiotherapy due to non-small call lung cancer
* Have been diagnosed any type of cancer other than cancer of skin, thyroid, uterine cervix within 5 years before enrollment
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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CytoGen, Inc.

INDUSTRY

Sponsor Role collaborator

UNIST (Ulsan National Institute of Science and Technology)

UNKNOWN

Sponsor Role collaborator

Samsung Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Jhingook Kim, MD

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jhingook Kim, MD

Role: STUDY_CHAIR

Samsung Medical Center

Locations

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Samsung Medical Center

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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IRB 2019-07-101

Identifier Type: -

Identifier Source: org_study_id

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