Hyperbaric Oxygen - a New Treatment Modality in Patients With Radiation Damaged Salivary Gland Tissue

NCT ID: NCT01606644

Last Updated: 2012-05-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-05-31

Study Completion Date

2014-04-30

Brief Summary

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Randomized clinical trial regarding the effect of hyperbaric oxygen on late radiation tissue injury to salivary gland tissue.

Detailed Description

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Conditions

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Late Effect of Radiation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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HBO

30 90-minute hyperbaric oxygen sessions at 2.4 atm.

Group Type EXPERIMENTAL

Hyperbaric oxygen

Intervention Type PROCEDURE

Inhalation of 100% oxygen for 90 minutes

No HBO

No intervention. No hyperbaric oxygen is administered. Otherwise, the patient will follow the examination program.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Hyperbaric oxygen

Inhalation of 100% oxygen for 90 minutes

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Head and neck cancer with planned radiation therapy
* Age \> 18 years

Exclusion Criteria

* Surgical treatment of head and neck cancer
* Salivary gland disease
* Severe claustrophobia
* Pregnancy or lactation (fertile women must use safe contraceptives)
* Uncontrolled hypertension (\> 220/110)
* Epilepsy
* Lack of ability to equalize inner ear pressure
* Pneumothorax
* Thoracic surgery within one month before HBO treatment
* Abuse of alcohol, drugs or narcotics
* Exposed titanium surfaces or defect titanium in the oral cavity
* Previous HBO treatment
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Danish Cancer Society

OTHER

Sponsor Role collaborator

Lone Forner

OTHER

Sponsor Role lead

Responsible Party

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Lone Forner

DDS, PhD

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Lone Forner, DDS, PhD

Role: PRINCIPAL_INVESTIGATOR

Copenhagen University Hospital at Herlev

Locations

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Department of Anaesthesia and Department of Oral and Maxillofacial Surgery, Copenhagen University Hospital

Copenhagen, , Denmark

Site Status RECRUITING

Countries

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Denmark

Central Contacts

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Lone Forner, DDS, PhD

Role: CONTACT

+45 3545 8211

Facility Contacts

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Lone Forner, DDS, PhD

Role: primary

+45 3545 8211

Erik C Jansen, MD. DMSc

Role: backup

+45 3545 1257

Other Identifiers

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HBO Copenhagen study

Identifier Type: -

Identifier Source: org_study_id

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