Local Metabolic Effects of Ghrelin in Skeletal Muscle and Adipose Tissue

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-06-30

Study Completion Date

2013-01-31

Brief Summary

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The metabolic effects of ghrelin is investigated by microdialysis technique. Subjects are healthy young men. End points are interstitial concentrations of glucose, lactate, and glycerol.

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Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Ghrelin

Group Type ACTIVE_COMPARATOR

Acyl ghrelin

Intervention Type DRUG

Acyl ghrelin 12.5 pg/min infused continuously for 300 minutes

Placebo

Ringer acetate is used for placebo.

Group Type PLACEBO_COMPARATOR

Placebo (Ringer acetate)

Intervention Type DRUG

Ringer acetate 2 microliter/min for 300 minutes

Interventions

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Acyl ghrelin

Acyl ghrelin 12.5 pg/min infused continuously for 300 minutes

Intervention Type DRUG

Placebo (Ringer acetate)

Ringer acetate 2 microliter/min for 300 minutes

Intervention Type DRUG

Other Intervention Names

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Human acyl ghrelin Ghrelin

Eligibility Criteria

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Inclusion Criteria

* healthy male
* age 18-65 years (included)
* Body mass index 20-25 (included)

Exclusion Criteria

* alcohol abuse
* malignant disease
* use of any medicine except otc painkillers
* any disease recognized
* participation in a trial using radioactive isotopes within the last 6 months

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes