Ghrelin Decreases Insulin Sensitivity

NCT ID: NCT00512525

Last Updated: 2009-09-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 8 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2003-01-31
• Study Completion Date: 2003-10-31

Brief Summary

Ghrelin administration increases appetite and, in rodents, induces weight gain. The aim of this study is to investigate the effect of short term ghrelin administration to humans on metabolism.

Detailed Description

The current study is initiated in order to assess the impact of acute ghrelin administration on insulin resistance measured by a hyperinsulinemic euglycemic clamp. Second, as free fatty acid is the predominant substrate during fasting, we aim to asses the effects of ghrelin on local and systemic lipolysis.

Conditions

Healthy Subjects

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: SINGLE

Study Groups

2

Group Type: PLACEBO_COMPARATOR

Ghrelin and saline (as placebo)

Intervention Type: DRUG

Intravenous infusion

Interventions

Ghrelin and saline (as placebo)

Intravenous infusion

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• healthy men, age >= 18 yr age < 50 yr, body mass index < 27.5 kg/m2above or equal to 18 yr

Exclusion Criteria

• any disease, use of prescribed medication, age < 18 yr or >= 50 yr

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Aarhus

OTHER

Sponsor Role: lead

Responsible Party

Aarhus University Hospital

Principal Investigators

Ole Schmitz, MD

Role: STUDY_DIRECTOR

Department of Pharmacology, University of Aarhus, Denmark

Other Identifiers

ETV2007

Identifier Type: -

Identifier Source: org_study_id