NAVISTAR® THERMOCOOL® SF Catheter: Observational Study

NCT ID: NCT01585961

Last Updated: 2015-01-26

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

511 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-04-30

Study Completion Date

2014-07-31

Brief Summary

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This is a prospective, interventional, observational, unblinded, single-arm, multicenter registry of younger and older subjects with drug refractory, recurrent, symptomatic paroxysmal atrial fibrillation.

Detailed Description

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This study is to measure the "real-world" acute procedural outcomes (procedural efficiency, acute safety, and effectiveness at one year) associated with use of the NAVISTAR® THERMOCOOL® SF Catheter in a clinical setting in subjects with drug refractory, recurrent symptomatic paroxysmal atrial fibrillation.

Conditions

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Atrial Fibrillation Paroxysmal Arrhythmia

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Catheter Ablation

These patients have drug refractory, recurrent, symptomatic paroxysmal atrial fibrillation, are aged 18 years or older, and have provided written informed consent to participate in the study, including consent to undergo catheter ablation with the study device.

Catheter Ablation (NAVISTAR® THERMOCOOL® SF Catheter)

Intervention Type DEVICE

Administer anesthesia according to standard EP lab protocol, assess the fluid status of the subject (after each liter of infusate), determine if diuresis is necessary, and treat accordingly.

Interventions

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Catheter Ablation (NAVISTAR® THERMOCOOL® SF Catheter)

Administer anesthesia according to standard EP lab protocol, assess the fluid status of the subject (after each liter of infusate), determine if diuresis is necessary, and treat accordingly.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Drug refractory, recurrent, symptomatic paroxysmal atrial fibrillation
* Age 18 years or older
* Patients must be able and willing to provide written informed consent to participate in the study

Exclusion Criteria

* Atrial fibrillation secondary to electrolyte imbalance, thyroid disease, or reversible or non-cardiac cause
* Previous ablation for atrial fibrillation
* Episodes of atrial fibrillation that last longer than 30 days and are terminated via cardioversion
* Uncontrolled heart failure, or NYHA Class III or IV heart failure
* Documented intra-atrial thrombus or other abnormality on pre-ablation echocardiogram
* Contraindication to anticoagulation
* Stroke, cardiac surgery, unstable angina, myocardial infarction or percutaneous coronary intervention within the past 3 months
* Awaiting cardiac transplantation
* Heart disease in which corrective surgery is anticipated within 6 months
* Enrollment in investigational drug, biologic or device study
* Subjects unwilling to comply with protocol or follow-up requirements
* Patients who are pregnant
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Biosense Webster, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gery Tomassoni, MD

Role: PRINCIPAL_INVESTIGATOR

Central Baptist Hospital

Scott Pollak, MD

Role: PRINCIPAL_INVESTIGATOR

Florida Hospital - Orlando

Andy Tran, MD

Role: PRINCIPAL_INVESTIGATOR

Scottsdale Healthcare Research Institute

Saumil Oza, MD

Role: PRINCIPAL_INVESTIGATOR

St. Vincent's Ambulatory Care, Inc.

Steven Compton, MD

Role: PRINCIPAL_INVESTIGATOR

Alaska Heart Institute, LLC

Anshul Patel, MD

Role: PRINCIPAL_INVESTIGATOR

St. Joseph's Hospital of Atlanta

Robert Fishel, MD

Role: PRINCIPAL_INVESTIGATOR

JFK Medical Center

Kenneth Civello, MD

Role: PRINCIPAL_INVESTIGATOR

Cardiovascular Research Foundation of Louisiana

Gaurang Gandhi, MD

Role: PRINCIPAL_INVESTIGATOR

Bethesda North Hospital

Alexandru Costea, MD

Role: PRINCIPAL_INVESTIGATOR

University of Cincinnati

Sreedhar Billakanty, MD

Role: PRINCIPAL_INVESTIGATOR

Riverside Methodist Hospital

H. James Wang, MD

Role: PRINCIPAL_INVESTIGATOR

Florida Hospital Memorial Medical Center

John Harding, MD

Role: PRINCIPAL_INVESTIGATOR

Central Bucks Specialists, Ltd.

Mohammed Khan, MD

Role: PRINCIPAL_INVESTIGATOR

Alexian Brothers Medical Center

Vijay Jayachandran, MD

Role: PRINCIPAL_INVESTIGATOR

Baylor All Saints Medical Center

Sree Karanam, MD

Role: PRINCIPAL_INVESTIGATOR

Lutheran Medical Group, LLC

M. Craig Delaughter, MD

Role: PRINCIPAL_INVESTIGATOR

Plaza Medical Center

Mohammad Jazayeri, MD

Role: PRINCIPAL_INVESTIGATOR

Bellin Memorial Hospital, Inc.

Abdi Rasekh, MD

Role: PRINCIPAL_INVESTIGATOR

Texas Heart Institute at St. Luke's Episcopal Hospital

Scott Allison, MD

Role: PRINCIPAL_INVESTIGATOR

Heart Center Research, LLC

Alexander Mazur, MD

Role: PRINCIPAL_INVESTIGATOR

University of Iowa Hospital & Clinics

Dhanunjaya Lakkireddy, MD

Role: PRINCIPAL_INVESTIGATOR

University of Kansas Hospitals

Alan Wimmer, MD

Role: PRINCIPAL_INVESTIGATOR

St. Luke's Hospital Mid American Heart Institute

Ali Hamzei, MD

Role: PRINCIPAL_INVESTIGATOR

Scripps Clinical Research

Shalin Shah, MD

Role: PRINCIPAL_INVESTIGATOR

Largo Medical Center

Michael Kutayli, MD

Role: PRINCIPAL_INVESTIGATOR

Bryan LGH Heart Institute

John Mandrola, MD

Role: PRINCIPAL_INVESTIGATOR

Baptist Hospital

Stuart Beldner, MD

Role: PRINCIPAL_INVESTIGATOR

North Shore University Hospital

Joshua Moss, MD

Role: PRINCIPAL_INVESTIGATOR

University of Chicago

Greg Bashian, MD

Role: PRINCIPAL_INVESTIGATOR

Centennial Heart

Patrick Whalen, MD

Role: PRINCIPAL_INVESTIGATOR

Vanderbilt Heart and Vascular Institute

Angelo Biviano, MD

Role: PRINCIPAL_INVESTIGATOR

New York Presbyterian Hospital, Columbia University Medical Center

Hussam Abuissa, MD

Role: PRINCIPAL_INVESTIGATOR

The Cardiac Center of Creighton University

Sumeet Mainigi, MD

Role: PRINCIPAL_INVESTIGATOR

Albert Einstein Medical Center

Charles Athill, MD

Role: PRINCIPAL_INVESTIGATOR

San Diego Cardiac Center

Edward Gerstenfeld, MD

Role: PRINCIPAL_INVESTIGATOR

UCSF Medical Center

Michael Chisner, MD

Role: PRINCIPAL_INVESTIGATOR

Cardiology Associates of Savannah

Vijendra Swarup, MD

Role: PRINCIPAL_INVESTIGATOR

Arizona Heart Hospital

Ziad Issa, MD

Role: PRINCIPAL_INVESTIGATOR

Prairie Education and Research Cooperative

Tariq Salam, MD

Role: PRINCIPAL_INVESTIGATOR

Cardiac Study Center

Sung Lee, MD

Role: PRINCIPAL_INVESTIGATOR

Washington Adventist Hospital

M. Magdy Migeed, MD

Role: PRINCIPAL_INVESTIGATOR

Genesis Healthcare Systems

Jonathan Sussman, MD

Role: PRINCIPAL_INVESTIGATOR

Morristown Medical Center

Bengt Herweg, MD

Role: PRINCIPAL_INVESTIGATOR

Tampa General Hospital

Pierce Vatterott, MD

Role: PRINCIPAL_INVESTIGATOR

United Heart and Vascular Clinic

Locations

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Heart Center Research, LLC

Huntsville, Alabama, United States

Site Status

Alaska Heart Institute, LLC

Anchorage, Alaska, United States

Site Status

Arizona Heart Hospital

Phoenix, Arizona, United States

Site Status

Scottsdale Healthcare Research Institute

Scottsdale, Arizona, United States

Site Status

Scripps Clinical Research

La Jolla, California, United States

Site Status

San Diego Cardiac Center

San Diego, California, United States

Site Status

UCSF Medical Center

San Francisco, California, United States

Site Status

JFK Medical Center

Atlantis, Florida, United States

Site Status

Florida Hospital Memorial Medical Center

Daytona Beach, Florida, United States

Site Status

St. Vincent's Ambulatory Care, Inc.

Jacksonville, Florida, United States

Site Status

Largo Medical Center

Largo, Florida, United States

Site Status

Florida Hospital - Orlando

Orlando, Florida, United States

Site Status

Tampa General Hospital

Tampa, Florida, United States

Site Status

St. Joseph's Hospital of Atlanta

Atlanta, Georgia, United States

Site Status

Cardiology Associates of Savannah

Savannah, Georgia, United States

Site Status

University of Chicago Medical Center

Chicago, Illinois, United States

Site Status

Alexian Brothers Medical Center

Elk Grove Village, Illinois, United States

Site Status

Prairie Education and Research Cooperative

Springfield, Illinois, United States

Site Status

Lutheran Medical Group, LLC

Fort Wayne, Indiana, United States

Site Status

University of Iowa Hospital & Clinics

Iowa City, Iowa, United States

Site Status

University of Kansas Hospitals

Kansas City, Kansas, United States

Site Status

Central Baptist Hospital

Lexington, Kentucky, United States

Site Status

Baptist Hospital

Louisville, Kentucky, United States

Site Status

Cardiovascular Research Foundation of Louisiana

Baton Rouge, Louisiana, United States

Site Status

Washington Adventist Hospital

Takoma Park, Maryland, United States

Site Status

United Heart and Vascular Clinic

Saint Paul, Minnesota, United States

Site Status

St. Luke's Mid American Heart Institute

Kansas City, Missouri, United States

Site Status

Bryan LGH Heart Institute

Lincoln, Nebraska, United States

Site Status

The Cardiac Center of Creighton University

Omaha, Nebraska, United States

Site Status

Morristown Medical Center

Morristown, New Jersey, United States

Site Status

North Shore University Hospital

Manhasset, New York, United States

Site Status

New York Presbyterian Hospital, Columbia University Medical Center

New York, New York, United States

Site Status

Bethesda North Hospital

Cincinnati, Ohio, United States

Site Status

University of Cincinnati

Cincinnati, Ohio, United States

Site Status

Riverside Methodist Hospital

Columbus, Ohio, United States

Site Status

Genesis Healthcare Systems

Zanesville, Ohio, United States

Site Status

Central Bucks Specialists, LTD

Doylestown, Pennsylvania, United States

Site Status

Albert Einstein Medical Center

Philadelphia, Pennsylvania, United States

Site Status

Centennial Heart

Nashville, Tennessee, United States

Site Status

Vanderbilt Heart and Vascular Institute

Nashville, Tennessee, United States

Site Status

Baylor All Saints Medical Center

Fort Worth, Texas, United States

Site Status

Plaza Medical Center

Grapevine, Texas, United States

Site Status

Texas Heart Institute at St. Luke's Episcopal Hospital

Houston, Texas, United States

Site Status

Cardiac Study Center

Tacoma, Washington, United States

Site Status

Bellin Memorial Hospital, Inc.

Green Bay, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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ThermoCool SF Phase IV

Identifier Type: -

Identifier Source: org_study_id

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