THERMOCOOL® SMARTTOUCH™ Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation

NCT ID: NCT01385202

Last Updated: 2025-02-04

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

172 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-06-30

Study Completion Date

2013-05-31

Brief Summary

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The purpose of this study is to demonstrate the safety and effectiveness of the THERMOCOOL® SMARTTOUCH™ Catheters with Contact Force Sensing Capability in the treatment of drug refractory symptomatic paroxysmal Atrial Fibrillation (AF) during standard electrophysiology mapping and RF procedures.

Detailed Description

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Conditions

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Heart Diseases Arrhythmia Atrial Fibrillation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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THERMOCOOL® SMARTTOUCH™ Catheter

Group Type EXPERIMENTAL

THERMOCOOL® SMARTTOUCH™ Catheter

Intervention Type DEVICE

AF Ablation

Interventions

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THERMOCOOL® SMARTTOUCH™ Catheter

AF Ablation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Have had at least 3 atrial fibrillation episodes within 6 months of this study
* Have failed at least one antiarrhythmic drug shown by repeated atrial fibrillation episodes
* 18 years of age or older

Exclusion Criteria

* Have had previous ablation for atrial fibrillation
* Have take amiodarone within 6 months of this study
* Have had any heart surgery within the last 60 days
* Have had a heart attack within the last 60 days
* Females who are pregnant or breast feeding
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Biosense Webster, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Andrea Natale, MD

Role: STUDY_CHAIR

Texas Cardiac Arrhythmia Research

David J Wilber, MD

Role: STUDY_CHAIR

Loyola University

Francis E Marchlinski, MD

Role: STUDY_CHAIR

University of Pennsylvania

Douglas L Packer, MD

Role: STUDY_CHAIR

Mayo Clinic

Hiroshi Nakagawa, MD, Ph.D.

Role: STUDY_CHAIR

University of Oklahoma

Hans Kottkamp, MD

Role: STUDY_CHAIR

University Leipzig

References

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Reddy VY, Pollak S, Lindsay BD, McElderry HT, Natale A, Kantipudi C, Mansour M, Melby DP, Lakkireddy D, Levy T, Izraeli D, Sangli C, Wilber D. Relationship Between Catheter Stability and 12-Month Success After Pulmonary Vein Isolation: A Subanalysis of the SMART-AF Trial. JACC Clin Electrophysiol. 2016 Nov;2(6):691-699. doi: 10.1016/j.jacep.2016.07.014. Epub 2016 Nov 21.

Reference Type DERIVED
PMID: 29759747 (View on PubMed)

Natale A, Reddy VY, Monir G, Wilber DJ, Lindsay BD, McElderry HT, Kantipudi C, Mansour MC, Melby DP, Packer DL, Nakagawa H, Zhang B, Stagg RB, Boo LM, Marchlinski FE. Paroxysmal AF catheter ablation with a contact force sensing catheter: results of the prospective, multicenter SMART-AF trial. J Am Coll Cardiol. 2014 Aug 19;64(7):647-56. doi: 10.1016/j.jacc.2014.04.072.

Reference Type DERIVED
PMID: 25125294 (View on PubMed)

Other Identifiers

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Smart-AF

Identifier Type: -

Identifier Source: org_study_id

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