Narrow QRS Ischemic Patients Treated With Cardiac Resynchronization Therapy (NARROW CRT)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-01-31

Brief Summary

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Current recommendations require a QRS duration of ≥120ms as a condition for prescribing cardiac resynchronization therapy (CRT). This study was designed to test the hypothesis that patients with heart failure of ischemic origin, current indications for defibrillator implantation and QRS \<120ms may benefit from CRT in the presence of marked mechanical dyssynchrony.

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Detailed Description

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Conditions

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Heart Failure, Systolic

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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CRT

The CRT group undergoes implantation of a CRT defibrillator

Group Type EXPERIMENTAL

cardiac resynchronization therapy

Intervention Type PROCEDURE

Implantation of a CRT defibrillator with a standard right atrial, right ventricular defibrillator and left ventricular leads

no-CRT

The no-CRT group receives a dual-chamber defibrillator

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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cardiac resynchronization therapy

Implantation of a CRT defibrillator with a standard right atrial, right ventricular defibrillator and left ventricular leads

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* NHYA class II-III heart failure
* ischemic cardiomyopathy
* ejection fraction of 35% or less
* QRS interval of 120ms or less
* evidence of mechanical dyssynchrony as measured on echocardiography