Efficacy of Over the Counter (OTC) Povidone-Ioldine 5% for Treatment of Acute or Chronic Blepharitis
NCT ID: NCT01560962
Last Updated: 2021-03-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
NA
100 participants
INTERVENTIONAL
2012-01-31
2012-12-31
Brief Summary
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Methodology: One hundred adult patients with chronic and acute blepharitis will be enrolled and randomized into four groups.
In group one, 25 patients will be instructed to scrub the lid margin of one eye with 5% PI twice daily for 10 days and the other eye with no intervention.
In group two, 25 patients will be instructed to scrub the lid margin of one eye with 5% PI and the other eye will receive warm soaked eyelid wash.
In group three, 25 patients will be instructed to scrub the lid margin of one eye with 5% PI and the other eye will receive 1 drop of azithromycin ophthalmic solution twice daily for 10 days.
In group four, 25 patients will be instructed to scrub the lid margin of one eye with 5% PI and the other eye will receive tobradex ointment applied to the lid margin.
Subjective variables assessed included itchiness, foreign body sensation and eyelid edema (grade 0-4). Objective variables assessed included lid margin redness, meibomian gland plugging and presence/absence of collarets (grade 0-4). Cultures of lid margin at the initiation and at the cessation of treatment were obtained.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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PI vs no intervention
In group one, 25 patients will be instructed to scrub the lid margin of one eye with 5% PI twice daily for 10 days and the other eye with no intervention.
povidone iodine
over the counter (OTC) 5% povidone iodine (PI)
No Intervention
PI vs hygiene
In group two, 25 patients will be instructed to scrub the lid margin of one eye with 5% PI and the other eye will receive warm soaked eyelid wash.
povidone iodine
over the counter (OTC) 5% povidone iodine (PI)
warm soaked eyelid wash
PI vs azasite
In group three, 25 patients will be instructed to scrub the lid margin of one eye with 5% PI and the other eye will receive 1 drop of azithromycin ophthalmic solution twice daily for 10 days.
povidone iodine
over the counter (OTC) 5% povidone iodine (PI)
Azithromycin
PI vs tobradex
In group four, 25 patients will be instructed to scrub the lid margin of one eye with 5% PI and the other eye will receive tobradex ointment applied to the lid margin.
povidone iodine
over the counter (OTC) 5% povidone iodine (PI)
tobramycin-dexmethasone
Interventions
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povidone iodine
over the counter (OTC) 5% povidone iodine (PI)
No Intervention
Azithromycin
tobramycin-dexmethasone
warm soaked eyelid wash
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
Yes
Sponsors
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Southern California Institute for Research and Education
OTHER
Responsible Party
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Locations
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Veterans Affairs Long Beach Healthcare System
Long Beach, California, United States
Countries
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Other Identifiers
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blepharitis
Identifier Type: -
Identifier Source: org_study_id
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