Effect of N-methyl D-aspartate (NMDA) Receptor Antagonist Dextromethorphan on Opiods Analgesia and Tolerance in Pediatric Intensive Care Unit Patients
NCT ID: NCT01553435
Last Updated: 2015-04-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
36 participants
INTERVENTIONAL
2011-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
SUPPORTIVE_CARE
QUADRUPLE
Study Groups
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Dextromethorphan, opioid analgisia, efficacy
Dextromethorphan
The study medicines shall be administered via tube.
Placebo,opioid analgesia, efficacy
Placebo
The study medicines shall be administered via tube.
Interventions
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Dextromethorphan
The study medicines shall be administered via tube.
Placebo
The study medicines shall be administered via tube.
Eligibility Criteria
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Inclusion Criteria
* On Morphine or Fentanyl infusions for more than 48 hours
Exclusion Criteria
* Patients with anticipated PICU length of stay less than 3 days.
* Patients shall be excluded if Morphine or Fentanyl infusions not continued for the minimum duration of 72 hours after enrollment
* Patients develops hemodynamic instability
* Patients with Hepatic failure
* Withdrawal request by parent(s)/guardian/family
2 Years
14 Years
ALL
No
Sponsors
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King Abdullah International Medical Research Center
OTHER
Responsible Party
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Mohammed Naeem
Consultant Pediatric Intensivist
Locations
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King Abdul Aziz Medical City
Riyadh, Central, Saudi Arabia
Countries
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References
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Naeem M, Al Alem H, Al Shehri A, Al-Jeraisy M. Effect of N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan on Opioid Analgesia in Pediatric Intensive Care Unit. Pain Res Manag. 2016;2016:1658172. doi: 10.1155/2016/1658172. Epub 2016 Oct 27.
Other Identifiers
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RC 09-120
Identifier Type: -
Identifier Source: org_study_id
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