Sedation Protocols and Skeletal Muscle Metabolism in Mechanical Ventilated Patients
NCT ID: NCT03402113
Last Updated: 2018-03-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
360 participants
INTERVENTIONAL
2017-12-20
2019-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Dexmedetomidine group
Dexmedetomidine consistent infusion as sedative.
Dexmedetomidine
consistent infusion at a loading dose of 0.15ug/kg/h, increased by 0.15ug/kg/h, with a maximum dose of 1.5ug/kg/h.
Midazolam group
Midazolam consistent infusion as sedative.
Midazolam
consistent infusion at a loading dose of 1mg/h, increased by 1mg/h, with a maximum dose of 10mg/h.
Interventions
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Dexmedetomidine
consistent infusion at a loading dose of 0.15ug/kg/h, increased by 0.15ug/kg/h, with a maximum dose of 1.5ug/kg/h.
Midazolam
consistent infusion at a loading dose of 1mg/h, increased by 1mg/h, with a maximum dose of 10mg/h.
Eligibility Criteria
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Inclusion Criteria
* 18-80 years
* stay in ICU for more than 5 days
Exclusion Criteria
* pregnancy or lactation
* lower limb amputation
* primary neuro-muscular disease
* disseminated tumor or accepted special therapy
* alcohol abuse
* severe liver dysfunction(Child-Push C)
* unstable angina/acute myocardial infarction
* heart rates\<50bpm
* all kinds dialysis
* severe burn
* epidural anesthesia
* severe neurological disease（acute stroke, uncontrollable epilepsy, severe dementia, etc）
18 Years
80 Years
ALL
No
Sponsors
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Chinese Medical Association
NETWORK
Responsible Party
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Locations
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The Affliated Drum Tower Hospital, Medical School of Nanjing University
Nanjing, Jiangsu, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Gulou ICU
Identifier Type: -
Identifier Source: org_study_id
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