Metformin for the Treatment of Unexplained Oligozspermia
NCT ID: NCT01529177
Last Updated: 2015-08-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
600 participants
INTERVENTIONAL
2012-02-29
2017-02-28
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Metformin / clomid / hCG
Metformin 1000 mg orally to be given daily for one week then twice daily for 2 weeks then 3 times daily for 6 months.
After 3 months from starting metformin the participant will receive 2 more medications in addition to metformin:
Clomid 50 mg orally per day and 5000 IU human chorionic gonadotrophin (hCG ) IM once per week for three months.
Metformin / clomid / hCG
Metformin 1000 mg daily for a week then twice daily for 2 weeks then 3 tomes daily for 6 months.
Clomid / hCG
Clomid 50 mg per day will be administered orally and human chorionic gonadotrophin ( choriomon ) 5000 IU will be administered IM once per week. Both medications will be given for 6 month.
Clomiphene citrate / hCG
Clomiphene citrate 50 mg daily for one month, then twice daily for 2 months then 3 times per day for 3 months.
Interventions
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Metformin / clomid / hCG
Metformin 1000 mg daily for a week then twice daily for 2 weeks then 3 tomes daily for 6 months.
Clomiphene citrate / hCG
Clomiphene citrate 50 mg daily for one month, then twice daily for 2 months then 3 times per day for 3 months.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* normal FSH
* high insulin
Exclusion Criteria
* obstructive azoospermia
25 Years
50 Years
MALE
No
Sponsors
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The Egyptian IVF-ET Center
OTHER
Responsible Party
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Ragaa Mansour
Director
Principal Investigators
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Ragaa mansour, MD,PhD
Role: PRINCIPAL_INVESTIGATOR
The Egyptian IVF-ET Center
Locations
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The Egyptian IVF-ET center
Cairo, Cairo Governorate, Egypt
Countries
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Facility Contacts
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Other Identifiers
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metformin for spermatogenesis
Identifier Type: -
Identifier Source: org_study_id
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