Metformin in Patients With PCOS and Predictors of Poor Ovarian Response Ongoing In-vitro Fertilization
NCT ID: NCT01208740
Last Updated: 2011-05-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
PHASE4
88 participants
INTERVENTIONAL
2009-01-31
2011-03-31
Brief Summary
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On the basis of these considerations, the aim of the current clinical trial was to test the hypothesis that metformin reduces the ovarian response in infertile patients with PCOS who have a potentially poor ovarian response and who undergo gonadotropin stimulation for IVF cycles.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Metformin
Metformin pre-treatment and co-administration
Metformin
500 mg three times daily
Placebo
Placebo pre-treatment and co-administration
Placebo
1 pill three times daily
Interventions
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Metformin
500 mg three times daily
Placebo
1 pill three times daily
Eligibility Criteria
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Inclusion Criteria
* Prognosis for poor response
* Infertility
Exclusion Criteria
* Tubal infertility
35 Years
45 Years
FEMALE
No
Sponsors
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University Magna Graecia
OTHER
Responsible Party
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University Magna Graecia
Principal Investigators
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Fulvio Zullo, MD
Role: STUDY_CHAIR
Department of Obstetrics and Gynecology, University "Magna Graecia" of Catanzaro
Stefano Palomba, MD
Role: PRINCIPAL_INVESTIGATOR
Department of Obstetrics and Gynecology, University "Magna Graecia" of Catanzaro
Locations
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Pugliese" Hospital
Catanzaro, Italy, Italy
Countries
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References
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Palomba S, Falbo A, Di Cello A, Cappiello F, Tolino A, Zullo F. Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial. Fertil Steril. 2011 Nov;96(5):1128-33. doi: 10.1016/j.fertnstert.2011.08.020. Epub 2011 Sep 13.
Other Identifiers
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02/2010
Identifier Type: -
Identifier Source: org_study_id
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