Natural History of Carotid Atherosclerosis

NCT ID: NCT01521351

Last Updated: 2019-09-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

700 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-01-31

Study Completion Date

2020-12-31

Brief Summary

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A prospective study of 700 patients with coronary artery disease will undergo non invasive evaluation of their carotid arteries by ultrasound and microwave radiometry. The patients will be followed up for 3 years and their outcome regarding the cardiovascular events (death, cardiac events, cerebrovascular events) will be recorded

Detailed Description

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Carotid artery Thermal heterogeneity recorded by MR will be corelated to cardiovascular events (death, cardiac events, cerebrovascular events) as well as to all demographic (age, sex, hypertension, dyslipidemia, smoking status, etc) factors

Conditions

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Carotid Artery Disease Stroke Myocardial Infarction Angina Pectoris

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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carotid thermal heterogeneity

Patients that have carotid thermal heterogeneity detected by MR

No interventions assigned to this group

no carotid thermal heterogeneity

Patients that DONT have carotid thermal heterogeneity detected by MR

No interventions assigned to this group

carotid artery disease

Patients with detected carotid artery disease by ultrasound

No interventions assigned to this group

no carotid artery disease

Patients with no carotid artery disease detected by ultrasound

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Consecutive patients with coronary artery disease admitted in our hospital

Exclusion Criteria

* Patients with history of previous cerebrovascular event,
* History of vasculitis, intermittent inflammatory, infectious, or neoplastic conditions likely to be associated with an acute-phase response.
Minimum Eligible Age

30 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National and Kapodistrian University of Athens

OTHER

Sponsor Role lead

Responsible Party

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Konstantinos Toutouzas

Associate Professor of Cardiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Konstantinos Toutouzas

Role: PRINCIPAL_INVESTIGATOR

First department of Cardiology, University of Athens Greece

Locations

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First Department of Cardiology, University of Athens, Medical School. Hippocratio Hospital

Athens, Attica, Greece

Site Status RECRUITING

Countries

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Greece

Central Contacts

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Konstantinos Toutouzas

Role: CONTACT

Andreas Synetos

Role: CONTACT

Facility Contacts

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Andreas Synetos, MD

Role: primary

00306945417784

References

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Toutouzas K, Grassos H, Synetos A, Drakopoulou M, Tsiamis E, Moldovan C, Agrogiannis G, Patsouris E, Siores E, Stefanadis C. A new non-invasive method for detection of local inflammation in atherosclerotic plaques: experimental application of microwave radiometry. Atherosclerosis. 2011 Mar;215(1):82-9. doi: 10.1016/j.atherosclerosis.2010.12.019. Epub 2010 Dec 23. No abstract available.

Reference Type BACKGROUND
PMID: 21256490 (View on PubMed)

Toutouzas K, Benetos G, Drakopoulou M, Deligianni C, Spengos K, Stefanadis C, Siores E, Tousoulis D. Incremental predictive value of carotid inflammation in acute ischemic stroke. Stroke. 2015 Jan;46(1):272-4. doi: 10.1161/STROKEAHA.114.007526. Epub 2014 Nov 4.

Reference Type BACKGROUND
PMID: 25370590 (View on PubMed)

Toutouzas K, Benetos G, Drakopoulou M, Bounas P, Tsekoura D, Stathogiannis K, Koutagiar I, Aggeli C, Karanasos A, Panagiotakos D, Siores E, Stefanadis C. Insights from a thermography-based method suggesting higher carotid inflammation in patients with diabetes mellitus and coronary artery disease. Diabetes Metab. 2014 Dec;40(6):431-8. doi: 10.1016/j.diabet.2014.05.005. Epub 2014 Jun 26.

Reference Type BACKGROUND
PMID: 24981292 (View on PubMed)

Toutouzas K, Benetos G, Drakopoulou M, Michelongona A, Nikolaou C, Masoura C, Stathogiannis K, Aggeli C, Tsiamis E, Siores E, Stefanadis C. Morphological and functional assessment of carotid plaques have similar predictive accuracy for coronary artery disease. Stroke. 2013 Sep;44(9):2607-9. doi: 10.1161/STROKEAHA.113.002462. Epub 2013 Jul 25.

Reference Type BACKGROUND
PMID: 23887842 (View on PubMed)

Toutouzas K, Benetos G, Oikonomou G, Barampoutis N, Koutagiar I, Galanakos S, Karmpalioti M, Drakopoulou M, Stathogiannis K, Bounas P, Gata V, Antoniadou F, Davlouros P, Alexopoulos D, Hahalis G, Siores E, Sfikakis PP, Tousoulis D. Increase in Carotid Temperature Heterogeneity Is Associated With Cardiovascular and Cerebrovascular Events. Circ Cardiovasc Imaging. 2018 Nov;11(11):e008292. doi: 10.1161/CIRCIMAGING.118.008292. No abstract available.

Reference Type DERIVED
PMID: 30571323 (View on PubMed)

Related Links

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Other Identifiers

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MRcar

Identifier Type: -

Identifier Source: org_study_id

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