Natural History of Atherosclerosis

NCT ID: NCT00918541

Last Updated: 2011-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-01-31

Study Completion Date

2010-03-31

Brief Summary

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20 patients will be recruited. The aim of the study is to determine the natural progression of atherosclerotic disease.

Detailed Description

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Conditions

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Atherosclerosis

Keywords

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atherosclerotic disease progression natural progression of atherosclerotic disease natural history of atherosclerosis at the level of the carotid artery as evaluated by MRI

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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A

asymptomatic patients with mild to moderate carotid artery stenosis

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* stable carotid artery disease not requiring revascularization
* asymptomatic carotid artery stenosis \< 80% or symptomatic patients with stenosis \< 60 %
* prophylactic therapy with aspirin (\> 100mg/day, statin, blood pressure therapy if indicated (goal \< 130/80 mmHg))
* informed consent

Exclusion Criteria

* non atherosclerotic occlusive disease (Bürgers disease)
* uncontrolled BP (DBP \> 110 mmHg and/or SBP \> 200 mmHg)
* hemorrhagic disease or platelet count \< 100'000 mm\^3
* Known active liver disease (elevations of GPT GOT or increased ammonia)
* impaired renal function (crea \> 180 mmol/l)
* pregnancy
* severe claustrophobic reactions
* short - term life - threatening pathology
* physically unable to participate in the study
* compliance not guaranteed
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Districthospital of Bellinzona

UNKNOWN

Sponsor Role collaborator

University of Zurich

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Roberto Corti, MD

Role: PRINCIPAL_INVESTIGATOR

Cardiovascular Center Cardiology, University Hospital Zürich, Zürich Switzerland

Augusto Gallino, MD

Role: PRINCIPAL_INVESTIGATOR

Ospedale San Giovanni Bellinzona, Switzerland

Locations

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Ospedale San Giovanni Bellinzona

Bellinzona, , Switzerland

Site Status

Ospedale San Giovanni

Bellinzona, , Switzerland

Site Status

Cardiovascular Center Cardiology University Hospital Zürich

Zurich, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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CarotidMRI

Identifier Type: -

Identifier Source: org_study_id