St.Jude Medical Cardiac Lead Assessment Study

NCT ID: NCT01507987

Last Updated: 2021-08-23

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2216 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-03-31

Study Completion Date

2019-09-30

Brief Summary

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The Cardiac Lead Assessment Study (CLAS) is designed as a prospective, non-randomized, multi-center, international postmarket surveillance study under 522 Order PS120111 (August 16, 2012).

Detailed Description

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The objective of this study was to determine the prevalence and incidence of externalized conductors and other visual lead anomalies (as evidenced by imaging) and the risk of progression to electrical dysfunction in subjects with one or more of the following St. Jude Medical (SJM) cardiac leads: Riata leads, Riata ST leads, Durata and/or QuickSite/QuickFlex Cardiac Resynchronization Therapy (CRT) leads.

Conditions

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Externalized Conductors Visual Lead Anomalies Electrical Dysfunction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with SJM leads implanted

Patient has at least one market released Riata, Riata ST, QuickSite/QuickFlex, or Durata lead implanted

Implanted with one or more of the following SJM leads: Riata leads, RiataST leads, Durata leads, and QuickSite/QuickFlex leads

Intervention Type DEVICE

Riata leads implanted between 2002-2009 Riata ST leads implanted between 2006-2009 Quicksite or QuickFlex leads implanted between 2006-2010 Durata leads implanted between 2008-2010

Subjects were followed for three years and cinefluoroscopy imaging was done annually to determine prevalence of externalized conductors or other visual lead anomalies

Interventions

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Implanted with one or more of the following SJM leads: Riata leads, RiataST leads, Durata leads, and QuickSite/QuickFlex leads

Riata leads implanted between 2002-2009 Riata ST leads implanted between 2006-2009 Quicksite or QuickFlex leads implanted between 2006-2010 Durata leads implanted between 2008-2010

Subjects were followed for three years and cinefluoroscopy imaging was done annually to determine prevalence of externalized conductors or other visual lead anomalies

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Patient has a market released SJM Implantable Cardioverter Defibrillator (ICD), CRT-D or CRT-P already implanted.
2. Patient has at least one market released Riata/ Riata ST/QuickSite/QuickFlex/Durata already implanted in which the lead model number and lead implant date is indicated in Table 1 (see protocol attached.)
3. Have the ability to provide informed consent for study participation and be willing to comply with the prescribed evaluations as detailed in this study plan.
4. Are 18 years or above

Exclusion Criteria

1. Patient is currently pregnant.
2. Enrolled or intend to participate in a clinical drug and/or device study, which could confound the results of this trial as determined by SJM, during the course of this clinical study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Medical Devices

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Cardiology, P.C.

Birmingham, Alabama, United States

Site Status

University Hospital of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

Heart Center Research

Huntsville, Alabama, United States

Site Status

Arizona Arrhythmia Consultants

Scottsdale, Arizona, United States

Site Status

Arkansas Heart Hospital

Little Rock, Arkansas, United States

Site Status

Scripps Green Hospital

La Jolla, California, United States

Site Status

Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, United States

Site Status

Cardiac Rhythm Specialists

Reseda, California, United States

Site Status

Mercy Medical Group

Sacramento, California, United States

Site Status

St. Joseph's Medical Center

Stockton, California, United States

Site Status

Penrose St. Francis Health Services

Colorado Springs, Colorado, United States

Site Status

Naples Heart Rhytm Specialists, PA

Naples, Florida, United States

Site Status

Redmond Regional Medical Center

Rome, Georgia, United States

Site Status

OSF Healthcare Cardiovascular Institute

Peoria, Illinois, United States

Site Status

Mid-America Cardiology Associates, PC

Kansas City, Kansas, United States

Site Status

Heart Clinic of Hammond, LLC

Hammond, Louisiana, United States

Site Status

Ochsner Medical Center

New Orleans, Louisiana, United States

Site Status

Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

Sparrow Clinical Research Institute

Lansing, Michigan, United States

Site Status

Jackson Heart Clinic

Jackson, Mississippi, United States

Site Status

Cardiology Associates of North Mississippi

Tupelo, Mississippi, United States

Site Status

Methodist Physicians Clinic-Heart Consultants

Omaha, Nebraska, United States

Site Status

Deborah Heart and Lung

Browns Mills, New Jersey, United States

Site Status

New Mexico Heart Institute

Albuquerque, New Mexico, United States

Site Status

Asheville Cardiology Associates

Asheville, North Carolina, United States

Site Status

The Cleveland Clinic Foundation

Cleveland, Ohio, United States

Site Status

Ohio State University

Columbus, Ohio, United States

Site Status

The Toledo Hospital

Toledo, Ohio, United States

Site Status

Providence Heart & Vascular Institute

Portland, Oregon, United States

Site Status

Saint Vincent Consultants in Cardiovascular Diseases

Erie, Pennsylvania, United States

Site Status

Drexel University College oF Medicine

Philadelphia, Pennsylvania, United States

Site Status

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States

Site Status

Donald Guthrie Foundation for Education and Research

Sayre, Pennsylvania, United States

Site Status

Wellspan Health

York, Pennsylvania, United States

Site Status

Sutherland Cardiology Clinic

Germantown, Tennessee, United States

Site Status

Mountain States Medical Group Cardiology

Johnson City, Tennessee, United States

Site Status

Arrhythmia Consultants

Memphis, Tennessee, United States

Site Status

South Texas Cardiovascular Consultants

San Antonio, Texas, United States

Site Status

University of Utah Hospital

Salt Lake City, Utah, United States

Site Status

Sentara Norfolk General Hospital

Norfolk, Virginia, United States

Site Status

Aurora Medical Group

Milwaukee, Wisconsin, United States

Site Status

QE II Health Sciences

Halifax, Nova Scotia, Canada

Site Status

University of Tsukuba Hospital

Tsukuba, Ibaraki, Japan

Site Status

Osaka City University Hospital

Osaka, Osaka, Japan

Site Status

Kyoto-Katsura Hospital

Kyoto, , Japan

Site Status

Countries

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United States Canada Japan

Provided Documents

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Document Type: Study Protocol, Statistical Analysis Plan, and Informed Consent Form

View Document

Other Identifiers

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CRD-619

Identifier Type: OTHER

Identifier Source: secondary_id

60039775/K

Identifier Type: -

Identifier Source: org_study_id

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