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Intubating Conditions During Propofol-remifentanil Anesthesia With Topical Lidocaine

NCT ID: NCT01489683

Last Updated: 2012-07-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-05-31

Study Completion Date

2012-05-31

Brief Summary

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When not using neuromuscular blocking agent, even at optimal dosage, target-controlled infusion (TCI) of propofol and remifentanil occasionally produce unsatisfactory intubating conditions. Therefore, the investigators evaluated that the effect of tracheal lidocaine on the intubating conditions for tracheal intubation during anesthesia induction of propofol and remifentanil TCI without neuromuscular blocking agent in day-case anesthesia.

Detailed Description

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Anesthesia was induced with propofol-remifentanil TCI with the effect-site concentration of 5μg/ml and 5ng/ml, respectively. After TCI, 3 ml of normal saline or 3 ml of 4% lidocaine was instilled to larynx and trachea, following intubation was performed.

Conditions

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Drug Usage

Keywords

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intubating conditions propofol remifentanil topical lidocaine

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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control

3 ml of normal saline was instilled to larynx and trachea

Group Type EXPERIMENTAL

lidocaine

Intervention Type DRUG

3 ml of 4% lidocaine was instilled to larynx and trachea

lidocaine

3 ml of 4% lidocaine was instilled to larynx and trachea before endotracheal intubation

Group Type ACTIVE_COMPARATOR

normal saline

Intervention Type DRUG

3 ml of normal saline was instilled to larynx and trachea before endotracheal intubation

Interventions

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lidocaine

3 ml of 4% lidocaine was instilled to larynx and trachea

Intervention Type DRUG

normal saline

3 ml of normal saline was instilled to larynx and trachea before endotracheal intubation

Intervention Type DRUG

Other Intervention Names

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4%lidocaine control

Eligibility Criteria

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Inclusion Criteria

* ASA I, II patients undergoing general anesthesia for reduction of nasal bone fracture

Exclusion Criteria

* bronchial asthma,
* COPD,
* hypertension,
* anticipated difficult airway
Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ajou University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Jong Yeop Kim

Associate professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jong Yeop Kim, MD

Role: STUDY_DIRECTOR

Ajou University School of Medicine

Locations

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Ajou University School of Medicine

Suwon, , South Korea

Site Status

Countries

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South Korea

References

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Bulow K, Nielsen TG, Lund J. The effect of topical lignocaine on intubating conditions after propofol-alfentanil induction. Acta Anaesthesiol Scand. 1996 Jul;40(6):752-6. doi: 10.1111/j.1399-6576.1996.tb04523.x.

Reference Type BACKGROUND
PMID: 8836274 (View on PubMed)

Other Identifiers

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AJIRB-MED-CT4-11-073

Identifier Type: -

Identifier Source: org_study_id