A Pilot Study to Evaluate Multi-Spectral and Laser Speckle Imaging and Multiphoton Microscopy During Vascular Occlusion

NCT ID: NCT01484730

Last Updated: 2025-12-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-11-30

Study Completion Date

2028-08-31

Brief Summary

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The purpose of this research is to evaluate and validate the performance of non-invasive imaging modalities for assessment of skin. A pressure cuff occlusion will be used to stimulate blood flow dynamic that these instruments are designed to sense. The researcher currently plan to assess only basic feasibility of the imaging instruments.

Detailed Description

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The primary reason for including pressure cuff occlusion in this protocol is to test the performance of Multi-Spectral Imaging and Laser Speckle Imaging can measure in the full range of vascular conditions ranging from ischemic (under-perfused or unsaturated) to hyperemic (over-perfused and over-saturated).

1. Modulated Imaging a non-contact optical imaging technology can detect the concentration of total hemoglobin, deoxygenated and oxygenated hemoglobin in absolute amounts in units of millimoles / unit volume of tissue measured.
2. Laser Speckle Imaging a non-contact optical imaging technology consists of a coherent light source, camera, and image acquisition system. This image device can measure and compare relative flow in vasculature at varied time points.

Conditions

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Abnormal Vascular Flow

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Vascular Occlusion

Multi-Spectral and Laser Speckle Imaging

Multi-Spectral and Laser Speckle Imaging

Intervention Type DEVICE

Changes in skin tissue and blood flow.

Interventions

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Multi-Spectral and Laser Speckle Imaging

Changes in skin tissue and blood flow.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Male and female adult 18 years and older

Exclusion Criteria

* Younger than 18 years of age
* Pregnant women
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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United States Department of Defense

FED

Sponsor Role collaborator

University of California, Irvine

OTHER

Sponsor Role lead

Responsible Party

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Anthony Joseph Durkin

Associate Researcher, BME & Surgery, Director, Laboratory for Functional Imaging Lab

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Anthony Durkin, PhD

Role: PRINCIPAL_INVESTIGATOR

University of California, Irvine

Locations

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Beckman Laser Institute and Medical Clinic

Irvine, California, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Gordon Kennedy, PhD

Role: CONTACT

949-824-4713

Facility Contacts

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Anthony Durkin, PhD

Role: primary

949-824-3284

Other Identifiers

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20118370

Identifier Type: -

Identifier Source: org_study_id

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