Pneumatic Compression vs Blood Flow Restriction for Muscle Recovery

NCT ID: NCT06815367

Last Updated: 2025-08-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

33 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-01-15

Study Completion Date

2025-12-01

Brief Summary

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Both BFR and intermittent pneumatic compression are purported to decrease symptoms associated with exercise induced muscle damage (EIMD) that cause delayed onset muscle soreness (DOMS). Blood flow restriction relies on applying pressurized cuffs to the most proximal portion of the limb. Another form of recovery often relied upon is pneumatic compression. The mechanism by which pneumatic compression works is similar to that of a massage, whereby the device progressively increases the pressure on a portion of the limb before releasing and moving further up the limb.The purpose of this study is determine whether BFR or pneumatic compression can be used to decreased DOMS which may indicate enhanced recovery.

Detailed Description

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Conditions

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Delayed Onset Muscle Soreness

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Control

The participants will be asked to refrain from exercise 24 hours prior to and following the exercise. Participants will complete all pre-exercise tests (DOMS, CMJ, MVIC). The exercise consists of running on a treadmill situated at a -10% grade at 9 km/hr (5.59 mph) for 20 minutes. This is proceeded and followed by 5 minute warm-up/cool-down periods.

Those that are allocated to the "control" group, will not receive treatment after the downhill running protocol.

Group Type NO_INTERVENTION

No interventions assigned to this group

Pneumatic compression

The participants will be asked to refrain from exercise 24 hours prior to and following the exercise. Participants will complete all pre-exercise tests (DOMS, CMJ, MVIC). The exercise consists of running on a treadmill situated at a -10% grade at 9 km/hr (5.59 mph) for 20 minutes. This is proceeded and followed by 5 minute warm-up/cool-down periods. Those allocated to the "pneumatic compression" group will receive 20 minutes of pneumatic compression at 100 mmHg.

Group Type EXPERIMENTAL

Pneumatic Compression

Intervention Type DEVICE

Following downhill running protocol, participants will complete 20 minutes of pneumatic compression at 100 mmHg.

Blood flow restriction

The participants will be asked to refrain from exercise 24 hours prior to and following the exercise. Participants will complete all pre-exercise tests (DOMS, CMJ, MVIC). The exercise consists of running on a treadmill situated at a -10% grade at 9 km/hr (5.59 mph) for 20 minutes. This is proceeded and followed by 5 minute warm-up/cool-down periods.

Those allocated to the "BFR" group will receive 4 rounds of treatment: 3 minutes will be spent at 100% of resting limb occlusion pressure, followed by 2 minutes of 0% occlusion.

Group Type EXPERIMENTAL

Blood Flow Restriction

Intervention Type DEVICE

Following the downhill running protocol, participants will complete 4 rounds of treatment: 3 minutes at 100% resting limb occlusion pressure, 2 minutes of 0% resting limb occlusion pressure.

Interventions

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Pneumatic Compression

Following downhill running protocol, participants will complete 20 minutes of pneumatic compression at 100 mmHg.

Intervention Type DEVICE

Blood Flow Restriction

Following the downhill running protocol, participants will complete 4 rounds of treatment: 3 minutes at 100% resting limb occlusion pressure, 2 minutes of 0% resting limb occlusion pressure.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* 18-30 years of age
* Recreationally active population
* Women should be on a form of hormonal contraception.
* No current musculoskeletal injuries or pathologies
* Must answer "yes" to all PAR-Q questions.

Exclusion Criteria

* Individuals that routinely train trail running
* Discomfort when running
* Deep vein thrombosis
* Blood clots
* Cancerous lesions
* Sensory or mental impairment
* Unstable fractures
* Acute pulmonary edema
* Acute thrombophlebitis
* Acute congestive cardiac failure
* Acute infections
* Episodes of pulmonary embolism
* Wounds, lesions, infection, or tumors
* Bone fractures or dislocations
* Increased venous and lymphatic return
* Answers "no" to any of the PAR-Q screening questions
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Southern California

OTHER

Sponsor Role lead

Responsible Party

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Todd Schroeder

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Southern California

Los Angeles, California, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Bailey McLagan, MS

Role: CONTACT

323-442-2498

Facility Contacts

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Bailey McLagan

Role: primary

323-442-2498

Other Identifiers

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HS-23-00594

Identifier Type: -

Identifier Source: org_study_id

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