The Enhancement Effect of Low-Level Laser Therapy for Muscle Training with Combined NMES and BFR

NCT ID: NCT06739148

Last Updated: 2024-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-01

Study Completion Date

2025-07-31

Brief Summary

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Blood flow restriction training (BFR) with neuromuscular stimulation (NMES) is employed for individuals with limited mobility and joint issues. However, this approach is highly susceptible to muscle fatigue, despite its potential beneficial effects on muscle strength. Recently, there has been growing interest in using low-level laser therapy (LLLT) to address muscle fatigue. LLLT, known for improving microcirculation and mitochondrial function, shows promise in alleviating enhanced muscle fatigue associated with combined BFR and NMES training. Despite these positive effects, there is limited knowledge about the short-term training impact of combined BFR and NMES with LLLT preconditioning. This project aims to investigate whether the photobiomodulation effects of LLLT could further enhance the training benefits of combined BFR and NMES. The study will employ an integrated analysis of decomposition surface EMG, EEG, and mechanomyogram to explore the behavior and neuromuscular mechanisms underlying the training benefits. If additional benefits are identified, LLLT pre-conditioning is recommended to enhance the use of combined BFR and NMES.

Detailed Description

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Conditions

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Blood Flow Restriction Therapy Neuromuscular Electrical Stimulation (NMES) Laser Therapy, Low-Level Muscle Strength

Keywords

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Muscle strength Training Low-level laser Therapy Blood flow restriction Neuromuscular electrical stimulation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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LLLT+BFR+NMES

LLLT: low-level laser therapy BFR: blood flow restriction NMES:neuromuscular Electrical Stimulation

35 min/time, 3 times/weeks, 3 weeks

Group Type EXPERIMENTAL

Low Level Laser Therapy

Intervention Type DEVICE

Low-level laser therapy can increase cellular energy production, making it useful as a pre-conditioning treatment to prevent muscle contraction fatigue or as a post-contraction therapy to accelerate fatigue recovery.

blood flow restriction

Intervention Type DEVICE

Its advantage is that during training, it can surpass the \"overload principle,\" allowing for effective muscle cross-sectional area growth with relatively light weight training (20%-50% of 1RM or 20%-40% of MVC).

Neuromuscular Electrical Stimulation

Intervention Type DEVICE

It is a strength training method that uses electrical currents to stimulate nerve and muscle activation, helping to maintain muscle mass, increase blood flow, and slow down or prevent muscle atrophy.

BFR+NMES

BFR: blood flow restriction NMES:Neuromuscular Electrical Stimulation

35 min/time, 3 times/weeks, 3 weeks

Group Type EXPERIMENTAL

blood flow restriction

Intervention Type DEVICE

Its advantage is that during training, it can surpass the \"overload principle,\" allowing for effective muscle cross-sectional area growth with relatively light weight training (20%-50% of 1RM or 20%-40% of MVC).

Neuromuscular Electrical Stimulation

Intervention Type DEVICE

It is a strength training method that uses electrical currents to stimulate nerve and muscle activation, helping to maintain muscle mass, increase blood flow, and slow down or prevent muscle atrophy.

Interventions

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Low Level Laser Therapy

Low-level laser therapy can increase cellular energy production, making it useful as a pre-conditioning treatment to prevent muscle contraction fatigue or as a post-contraction therapy to accelerate fatigue recovery.

Intervention Type DEVICE

blood flow restriction

Its advantage is that during training, it can surpass the \"overload principle,\" allowing for effective muscle cross-sectional area growth with relatively light weight training (20%-50% of 1RM or 20%-40% of MVC).

Intervention Type DEVICE

Neuromuscular Electrical Stimulation

It is a strength training method that uses electrical currents to stimulate nerve and muscle activation, helping to maintain muscle mass, increase blood flow, and slow down or prevent muscle atrophy.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Healthy adults aged 20-40, without a diagnosis of cardiovascular or neuromusculoskeletal diseases.
2. Normal vision range after visual correction.

Exclusion Criteria

1. Exclude students who have a teacher-student relationship with the principal investigator to ensure the participants\' autonomy.
2. History of brain injury, stroke, spinal cord injury, or other neuromuscular-related conditions.
3. Contraindications for laser therapy: pregnancy, malignant tumor tissues, bleeding areas, and photosensitive skin regions.
4. Presence of any contraindications for blood flow restriction training, such as a history of injury or strain in the non-dominant arm\'s biceps, deep vein thrombosis or venous occlusion in the non-dominant arm, acute unstable fractures in the non-dominant arm, acute regional infections in the non-dominant arm, severe peripheral arterial occlusive disease in the non-dominant arm, complete lymphatic obstruction in the non-dominant arm, and edema due to acute pulmonary edema or congestive heart failure in the non-dominant arm.
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Cheng-Kung University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ing-Shiou Hwang, PhD

Role: STUDY_CHAIR

NCKU, Institute of Allied Health Sciences

Locations

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National Chen Kong University Hospital, Tainan

Tainan City, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Ing-Shiou Hwang, PhD

Role: CONTACT

Phone: +886 62353535

Email: [email protected]

Pei-Fen Li, Master

Role: CONTACT

Phone: +886 62353535

Email: [email protected]

Facility Contacts

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Ing-Shiou Hwang, PhD

Role: primary

Other Identifiers

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A-ER-113-089

Identifier Type: -

Identifier Source: org_study_id