French Biological Observatory on Lung Cancer in Never Smokers
NCT ID: NCT01465854
Last Updated: 2023-05-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
422 participants
OBSERVATIONAL
2011-11-30
2013-01-31
Brief Summary
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Detailed Description
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For these reasons and considering that LCINS is an increasing public health problem, IFCT (Intergroupe Francophone de Cancérologie Thoracique) states to promote the BioCAST study (IFCT-1002). It is a national, multicentric, prospective epidemiological study. Main objective is to describe the clinical and molecular epidemiology of LCINS in a French population composed by all cases newly diagnosed in participating centres (500 to 1500 patients expected). BioCAST include a clinical and a biological part. The clinical component is based on collecting data directly from the patient through a standardized questionnaire during a telephone interview with a health professional. The biologic component includes a blood sample collection. A large genomic wide association study and an epigenetic study (including micro RNA study) are also planned. Other objectives are looking for correlations between clinical factors and molecular abnormalities; and looking for new oncogene in this specific population.
BioCAST hopes to provide concrete answers to clinicians and patients about this new and frequent entity.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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LCINS
Never smokers with newly diagnosed lung cancer
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* at least 18 years of age
* newly diagnosed lung cancer
* patient having access to a telephone
* french-speaking patient or patient who could be easily helped in his mother tongue during a phone interview
* signed informed consent
Exclusion Criteria
* chemotherapy already initiated at enrollment
18 Years
ALL
No
Sponsors
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Intergroupe Francophone de Cancerologie Thoracique
OTHER
Responsible Party
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Principal Investigators
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Sebastien COURAUD, MD
Role: PRINCIPAL_INVESTIGATOR
Hospices Civils de Lyon, CH Lyon Sud, FRANCE
Locations
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Centre Hospitalier du Pays d'Aix
Aix-en-Provence, , France
CHD Castelluccio
Ajaccio, , France
Clinique Claude Bernard
Albi, , France
CHU d'Angers
Angers, , France
CHI Annemasse-Bonneville
Annemasse, , France
CH Annonay
Annonay, , France
Hôpital Privé d'Antony
Antony, , France
CHIC
Aulnay-sous-Bois, , France
CH de la Côte Basque
Bayonne, , France
CHU Besançon
Besançon, , France
Hôpital Ambroise Paré - Pneumologie
Boulogne, , France
Hôpital Fleyriat
Bourg-en-Bresse, , France
CH Jacques-Cœur - Pneumologie
Bourges, , France
CH Pierre Oudot
Bourgoin, , France
HCL Hôpital Louis Pradel
Bron, , France
Centre François Baclesse
Caen, , France
CHU Côte de Nâcre
Caen, , France
CH Cahors
Cahors, , France
CH de Cannes
Cannes, , France
CH Chambery
Chambéry, , France
CH de Chartres Hôpital Louis Pasteur
Chartres, , France
CH de Chauny
Chauny, , France
Centre Médical Nicolas de Pontoux
Châlon-sur-Saône, , France
CH de Châlons-en-Champagne
Châlons-en-Champagne, , France
Hôpital de Cholet - Pneumologie
Cholet, , France
HIA Percy - Pneumologie
Clamart, , France
Hôpitral Gabriel Montpied - Pneumologie
Clermont-Ferrand, , France
Hôpital Pasteur
Colmar, , France
CH Compiègne - Pneumologie
Compiègne, , France
CHI Créteil
Créteil, , France
CH de Dax
Dax, , France
Cabinet privé
Dijon, , France
Centre d'Oncologie du Parc
Dijon, , France
Centre Georges François Leclerc
Dijon, , France
CHU Hôpital du Bocage
Dijon, , France
CHRU Grenoble
Grenoble, , France
CH Région Saint-Omer
Helfaut, , France
CH Lagny-sur-Marne
Lagny-sur-Marne, , France
CH de Versailles
Le Chesnay, , France
CH du Mans
Le Mans, , France
Centre Oscar Lambret
Lille, , France
Hôpital Calmette
Lille, , France
CH de Longjumeau
Longjumeau, , France
CH Lyon Sud - Pneumologie
Lyon, , France
CH Saint Joseph Saint Luc
Lyon, , France
Clinique Mutualiste Eugène André
Lyon, , France
HIA Desgenettes
Lyon, , France
Hôpital de la Croix Rousse
Lyon, , France
Hôpital Ambroise Paré
Marseille, , France
Hôpital Nord - Oncologie Multidisciplinaire & Innovations Thérapeutiques
Marseille, , France
Polyclinique du Parc
Maubeuge, , France
CH de Macon
Mâcon, , France
CHR Metz Thionville
Metz, , France
CH de Mont-De-Marsan
Mont-de-Marsan, , France
CH Montélimar
Montélimar, , France
CH de Mulhouse
Mulhouse, , France
CHU Nancy
Nancy, , France
Hôpital Laënnec - CHU de Nantes
Nantes, , France
CH Nevers
Nevers, , France
Centre Antoine Lacassagne
Nice, , France
CHR d'Orléans La Source
Orléans, , France
GH Paris Saint-Joseph
Paris, , France
Hôpital Bichat - Claude - Bernard
Paris, , France
Hôpital Saint Antoine
Paris, , France
Hôpital Tenon
Paris, , France
CH de Rambouillet
Rambouillet, , France
Institut Jean Godinot
Reims, , France
CHU Charles Nicolle
Rouen, , France
CH de Saint-Brieuc
Saint-Brieuc, , France
Institut de Cancérologie de la Loire
Saint-Priest-en-Jarez, , France
CHU Strasbourg
Strasbourg, , France
Hôpital Foch
Suresnes, , France
Hôpitaux du Léman - Pneumologie et Maladies Infectieuses
Thonon-les-Bains, , France
Hôpital Font-Pré - Pneumologie
Toulon, , France
Clinique Pasteur
Toulouse, , France
Clinique Saint Jean du Languedoc
Toulouse, , France
Hôpital Larrey - Pneumologie
Toulouse, , France
CHU Tours - Pneumologie
Tours, , France
CH Valence
Valence, , France
CHI de la Haute-Saône - Pneumologie
Vesoul, , France
Clinique Mutualiste Les Portes du Sud
Vénissieux, , France
CH de Villefranche - Pneumologie
Villefranche, , France
Countries
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References
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Couraud S, Debieuvre D, Moreau L, Dumont P, Margery J, Quoix E, Duvert B, Cellerin L, Baize N, Taviot B, Coudurier M, Cadranel J, Missy P, Morin F, Mornex JF, Zalcman G, Souquet PJ; BioCAST/IFCT-1002 study investigators. No impact of passive smoke on the somatic profile of lung cancers in never-smokers. Eur Respir J. 2015 May;45(5):1415-25. doi: 10.1183/09031936.00097314. Epub 2015 Mar 5.
Couraud S, Souquet PJ, Paris C, Do P, Doubre H, Pichon E, Dixmier A, Monnet I, Etienne-Mastroianni B, Vincent M, Tredaniel J, Perrichon M, Foucher P, Coudert B, Moro-Sibilot D, Dansin E, Labonne S, Missy P, Morin F, Blanche H, Zalcman G; French Cooperative Intergroup IFCT. BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers. Eur Respir J. 2015 May;45(5):1403-14. doi: 10.1183/09031936.00097214. Epub 2015 Feb 5.
Couraud S, Vaca-Paniagua F, Villar S, Oliver J, Schuster T, Blanche H, Girard N, Tredaniel J, Guilleminault L, Gervais R, Prim N, Vincent M, Margery J, Larive S, Foucher P, Duvert B, Vallee M, Le Calvez-Kelm F, McKay J, Missy P, Morin F, Zalcman G, Olivier M, Souquet PJ; BioCAST/IFCT-1002 investigators. Noninvasive diagnosis of actionable mutations by deep sequencing of circulating free DNA in lung cancer from never-smokers: a proof-of-concept study from BioCAST/IFCT-1002. Clin Cancer Res. 2014 Sep 1;20(17):4613-24. doi: 10.1158/1078-0432.CCR-13-3063. Epub 2014 Jul 10.
Couraud S, Labonne S, Missy P, Morin F, Tran Q, Deroy A, Milleron B, Blanche H, Zalcman G, Souquet PJ; les membres du Groupe de travail << non-fumeurs de l'IFCT >>. [Lung cancer in never smokers: a French national cohort (BioCAST/IFCT-1002)]. Rev Mal Respir. 2013 Sep;30(7):576-83. doi: 10.1016/j.rmr.2013.03.006. Epub 2013 May 18. French.
Fontaine-Delaruelle C, Mazieres J, Cadranel J, Mastroianni B, Dubos-Arvis C, Dumont P, Monnet I, Pichon E, Locatelli-Sanchez M, Dixmier A, Coudert B, Fraboulet S, Foucher P, Dansin E, Baize N, Vincent M, Missy P, Morin F, Moro-Sibilot D, Couraud S; IFCT10-02 BioCAST investigators. Somatic profile in lung cancers is associated to reproductive factors in never-smokers women: Results from the IFCT-1002 BioCAST study. Respir Med Res. 2020 Mar;77:58-66. doi: 10.1016/j.resmer.2020.01.003. Epub 2020 Jan 31.
Paris C, Do P, Mastroianni B, Dixmier A, Dumont P, Pichon E, Chouaid C, Coudert B, Foucher P, Fraboulet S, Locatelli-Sanchez M, Baize N, Dansin E, Moreau L, Vincent M, Missy P, Morin F, Moro-Sibilot D, Couraud S; BioCAST/IFCT-1002 study investigators; to the BioCAST/IFCT- 1002 study. Association between lung cancer somatic mutations and occupational exposure in never-smokers. Eur Respir J. 2017 Oct 26;50(4):1700716. doi: 10.1183/13993003.00716-2017. Print 2017 Oct.
Related Links
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Official website
Other Identifiers
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IFCT-1002 BioCAST
Identifier Type: -
Identifier Source: org_study_id
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