An Observational Study of Predictors and Outcomes of Lung Cancer in Never-smokers in the UK

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

225 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-09-17

Study Completion Date

2029-09-30

Brief Summary

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The goal of this observational study is to improve the early detection of lung cancer in adults who have smoked less than 100 tobacco cigarettes ("never-smokers") in the United Kingdom. The main questions it aims to answer are:

* To describe characteristics such as demographics, co-morbidities and environmental exposures
* To describe participant pathways including presentation mode and symptoms to understand if earlier diagnosis would be possible
* To describe participant outcomes such as cancer stage, treatment and mortality
* To quantitatively or qualitatively measure modifiable and non-modifiable factors that may be associated with LCINS including environmental measures, blood tests and genomic data.

Participants will currently have no change to their usual care.

Detailed Description

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Conditions

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Lung Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* All adult participants from age of 18 who are diagnosed or treated with primary lung cancer through radiology or histology at any participating study site

Exclusion Criteria

* Participants who have ever smoked cigarettes or tobacco will be excluded; this is defined as:

* More than 100 cigarettes or 75g tobacco in their lifetime
* Those who have received a prescription for nicotine replacement therapy
* For prospective participants, those who cannot consent will be excluded

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Neal Navani

Professor of Respiratory Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University College London Hospital

London, , United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Neal Navani, PhD

Role: CONTACT

Phone: 020 7679 2000

Email: [email protected]

Sindhu Naidu, MBBS