Cognitive Remediation for Neuropsychological Impairment in Compulsive Hoarding
NCT ID: NCT01451697
Last Updated: 2019-05-20
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
COMPLETED
Clinical Phase
EARLY_PHASE1
Total Enrollment
20 participants
Study Classification
INTERVENTIONAL
Study Start Date
2011-07-31
Study Completion Date
2012-10-31
Brief Summary
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The primary aim of this pilot randomized controlled trial is to examine whether cognitive remediation, compared to a placebo, improves attention and related cognitive functions in patients with compulsive hoarding. The primary hypothesis is that compulsive hoarding patients who are treated with cognitive remediation will demonstrate improved cognitive skills at post-treatment compared to patients receiving placebo. This will be especially true of attention; memory and executive function skills may also be improved.
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Detailed Description
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The primary aim of this pilot randomized controlled trial is to examine whether cognitive remediation, compared to a placebo, improves attention and related cognitive functions in patients with compulsive hoarding. Previous research has demonstrated that hoarders have diminished neuropsychological abilities, particularly in the areas of attention, memory, and executive function; and that cognitive remediation improves those functions in populations that are similarly impaired, such as in individuals with schizophrenia. The investigators will thus randomize 20 patients with compulsive hoarding to receive either cognitive remediation or a placebo condition. Before and after treatment, the investigators aim to assess the effects of cognitive remediation on neuropsychological functioning and hoarding severity. The primary specific aim is to examine whether cognitive remediation improves cognitive function in compulsive hoarders. The investigators hypothesize that compulsive hoarding patients who are treated with cognitive remediation will demonstrate improved cognitive skills at post-treatment compared to patients receiving placebo. This will be especially true of attention; memory and executive function skills may also be improved. A secondary, exploratory aim is to examine whether cognitive remediation improves hoarding severity, compared to placebo. The ultimate goal of this research is to determine the feasibility and appropriateness of pursuing larger-scale studies of the promising new approach of combining cognitive remediation with other treatments for compulsive hoarding-particularly cognitive-behavioral therapy (CBT).
Conditions
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Hoarding Disorder
Attentional Impairment
Study Design
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Allocation Method
RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
TREATMENT
Blinding Strategy
NONE
Study Groups
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Experimental: Cognitive Remediation
The remediation intervention will consist of a sequence of computerized cognitive exercises designed to improve a variety of aspects of attention, through repeated drill-and-practice (Bell, Bryson, Greig, Corcoran, \& Wexler, 2001; Bracy, 1995; Kurtz et al., 2007). Exercises will be started and continued at the highest level of difficulty, in order to best establish improvement over time. Components of the planned intervention produce performance gains on practiced tasks (e.g., Wexler et al., 1997) and generalization of improvement to other tasks (Kurtz et al., 2007). All training on computer exercises will be conducted with coaching from staff trained in these procedures.
Group Type
EXPERIMENTAL
Cognitive Remediation
Intervention Type
BEHAVIORAL
A computerized cognitive remediation program focused on attentional training will be used.
Control (Placebo)
The placebo control condition will consist of structured relaxation training, which will involve viewing and participating with meditation and stress-reduction DVDs, and listening to and following a CD of Progressive Muscle Relaxation. Participants will benefit from learning stress reduction techniques in this condition, but will not exercise any of the cognitive domains of interest targeted in the treatment group.
Group Type
PLACEBO_COMPARATOR
Control (Placebo)
Intervention Type
BEHAVIORAL
The control condition will involve relaxation training.
Interventions
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Cognitive Remediation
A computerized cognitive remediation program focused on attentional training will be used.
Intervention Type
BEHAVIORAL
Control (Placebo)
The control condition will involve relaxation training.
Intervention Type
BEHAVIORAL
Eligibility Criteria
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Inclusion Criteria
* be over 18 years of age,
* have a current primary diagnosis of hoarding disorder
* have no untreated and/or unstable concurrent psychiatric diagnoses
* have a score on the ADHDSS that is one standard deviation or more above the mean
* have an Attentional Composite score on the computerized battery of neuropsychological tests (Doniger, 2010) that is one standard deviation or more below the mean
* be stable on all psychotropic medications during and up to four weeks preceding enrollment in the study
* have a current primary diagnosis of hoarding disorder
* have no untreated and/or unstable concurrent psychiatric diagnoses
* have a score on the ADHDSS that is one standard deviation or more above the mean
* have an Attentional Composite score on the computerized battery of neuropsychological tests (Doniger, 2010) that is one standard deviation or more below the mean
* be stable on all psychotropic medications during and up to four weeks preceding enrollment in the study
Exclusion Criteria
* currently taking any cognitive enhancers or stimulants
* people with a history of Multiple Sclerosis, Traumatic Brain Injury, loss of consciousness lasting more than 5 minutes, seizures, dementia, or other organic brain-related disorders
* current Alcohol or Substance Abuse and/or a history of Alcohol or Substance Dependence
* people with a history of Multiple Sclerosis, Traumatic Brain Injury, loss of consciousness lasting more than 5 minutes, seizures, dementia, or other organic brain-related disorders
* current Alcohol or Substance Abuse and/or a history of Alcohol or Substance Dependence
Minimum Eligible Age
18 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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Hartford Hospital
OTHER
Sponsor Role
lead
Responsible Party
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Responsibility Role
SPONSOR
Principal Investigators
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Jennifer DiMauro, BA
Role: PRINCIPAL_INVESTIGATOR
Hartford Hospital
David F Tolin, PhD
Role: STUDY_DIRECTOR
Hartford Hospital
Locations
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Anxiety Disorders Center, Institute of Living/Hartford
Hartford, Connecticut, United States
Site Status
Countries
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United States
References
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Other Identifiers
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DIMA003472HI
Identifier Type: -
Identifier Source: org_study_id
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