Human Skin Aging: Clinical Parameters and Gene Expression Profiling

NCT ID: NCT01451476

Last Updated: 2024-02-09

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 122 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-05-31
• Study Completion Date: 2015-12-31

Brief Summary

Skin aging is a complex process involving genetic and environmental factors. The investigators hope to learn more about how human genes and their function can contribute to skin aging and human health.

Detailed Description

This study includes answering a survey on prior sun exposures, donating two small pieces of skin (4mm each), one blood draw, complexion analysis, photographs, and non-invasive tests such as skin surface lipid analysis. Your blood and tissue will be sent for DNA analysis and gene expression profiling.

Conditions

Ageing

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Healthy females aged >=18

Healthy female volunteers of skin type I or II

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• healthy female, age 18 or older,
• Fitzpatrick type 1 or 2 skin,
• able to read and understand written consent form,
• body mass index normal or overweight range,
• willing to take blood tests and donate skin samples

Exclusion Criteria

• pregnant or lactating,
• history of cosmetic surgery affecting the face,
• use of prescription anti-aging medications for 2 weeks prior to study,
• use of dietary supplements for 2 weeks prior to study, use of tanning beds or excessive light exposure (>2 hours) in the past 2 weeks,
• medical conditions which at the discretion of the investigator will have significant impact on ability to judge subjects' skin characteristics and age, sunless tanner use in past 2 weeks

• Minimum Eligible Age: 18 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Stanford University

OTHER

Sponsor Role: lead

Responsible Party

Anne Chang

instructor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Alfred Lane, MD

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Anne Chang, MD

Role: STUDY_DIRECTOR

Stanford University

Locations

Stanford Dermatology

Redwood City, California, United States

Countries

United States

References

Xu J, Spitale RC, Guan L, Flynn RA, Torre EA, Li R, Raber I, Qu K, Kern D, Knaggs HE, Chang HY, Chang AL. Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing. PLoS One. 2016 Nov 9;11(11):e0165913. doi: 10.1371/journal.pone.0165913. eCollection 2016.

Reference Type: RESULT

PMID: 27829007 (View on PubMed)

Other Identifiers

003

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

HSA_GEP

Identifier Type: -

Identifier Source: org_study_id