Effect of Pistachio Intake on Insulin Resistance and Type 2 Diabetes Mellitus

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-09-30

Study Completion Date

2017-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Hypothesis: Chronic intake of pistachios improves glucose metabolism and insulin resistance status thus contributing to decrease the risk of type 2 diabetes mellitus and its associated abnormalities.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Pistachios Blood Sugar Control, Heart and Gut Health

NCT04056208

Type 2 Diabetes Cardiovascular Diseases

COMPLETED PHASE2

Effects of Pistachios on Cardiovascular Responses to Stress in Type 2 Diabetes

NCT00956735

Cardiovascular Disease Type 2 Diabetes

COMPLETED NA

A Pragmatic Randomized Controlled Trial of Health Impact of Pistachios on Women With Gestational Diabetes Mellitus

NCT05694520

Gestational Diabetes Mellitus in Pregnancy

UNKNOWN NA

Effect of Nuts vs. a Wheat Bran Muffin in Type 2 Diabetes

NCT00410722

Type 2 Diabetes Cardiovascular Disease Diet Therapy

UNKNOWN PHASE2

Extra Virgin Olive Oil on Glycemic Control ,Insulin Resistance and Insulin Secretion

NCT03891927

Insulin Resistance

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

In free-living overweight or obese adult with impaired fasting glucose or impaired glucose tolerance we will compare the effects of a pistachio-rich diet or a Mediterranean Diet on:

* Fasting glucose levels, hemoglobin A1c, insulin, C peptide, HOMA IR, advanced glycation end products and soluble receptor of advanced glycation-end products.
* Peripheral haemostatic parameters.
* Plasma inflammatory markers.
* Lymphocyte expression of toll-like receptors, C peptide, resistin and interleukin-6 in peripheral leukocytes.
* Lymphocyte glucose transport and expression of glucose transporter 4 in peripheral blood leukocytes.
* Platelet function including platelet number, mean platelet volume, platelet factor 4 levels and urinary 11-dehydro-thromboxane B2.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Type 2 Diabetes Mellitus

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Control diet

Low-fat normocaloric diet (30% fat, 55% carbohydrates, 15% proteins)

Group Type ACTIVE_COMPARATOR

control diet

Intervention Type OTHER

Participants are randomised crossover clinical trial of 4-months trials separated by a 2-week washout period.

Total duration of intervention and follow-up is nine months.

Pistachio diet

Diet supplemented with 2 ounces of pistachio (35% fat, 50% carbohydrates adn 15% protein)

Group Type EXPERIMENTAL

Pistachios

Intervention Type DIETARY_SUPPLEMENT

Participants are randomised crossover clinical trial of 4-months trials separated by a 2-week washout period.

Total duration of intervention and follow-up is nine months.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Pistachios

Participants are randomised crossover clinical trial of 4-months trials separated by a 2-week washout period.

Total duration of intervention and follow-up is nine months.

Intervention Type DIETARY_SUPPLEMENT

control diet

Participants are randomised crossover clinical trial of 4-months trials separated by a 2-week washout period.

Total duration of intervention and follow-up is nine months.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* BMI less than 35 kg/m2.
* Fasting plasma glucose levels between 100 and 125 mg/dl or
* Oral glucose tolerance test of 140 to 199 mg/dl.

Exclusion Criteria

* Diabetes mellitus.
* Alcohol, tobacco, or drug abuse.
* Significant liver, kidney, thyroid, or other endocrine diseases.
* Frequent consumption of nuts or known history of allergy to them.
* Use of plant sterol, oral antidiabetic drugs, supplemental use of phyllium, fish oil supplements and multivitamins, vitamin E or other antioxidant supplements.
* Bad dentures, implying difficulty to chew pistachios.
* Being pregnant or wishing to become a pregnant 6 months before or during the study, lactating 6wk before or during the study.
* Following vegetarian or weight loss diets.
* Other medical or social conditions that difficult the compliance to the intervention.

Minimum Eligible Age

25 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No