Changes in the Permeability of the Blood Brain Barrier and Intestinal Barrier in Humans During Conditions of Stress and Immune Activation: in Vivo Studies

NCT ID: NCT01417416

Last Updated: 2011-08-16

Basic Information

• Recruitment Status: COMPLETED
• Study Classification: OBSERVATIONAL

Brief Summary

The relevance of BBB and IB permeability changes as a major precipitating cause for cognitive and digestive dysfunction in the military stress setting.

Conditions

Combat Training Stress

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

with combat training stress

No interventions assigned to this group

without combat training stress

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Healthy male troops (aged 18-50 yrs) scheduled to be engaged in a protracted multi-day stressful field exercises.

Exclusion Criteria

• Significantly systemic disease, including cardiovascular, psychiatric, neurological (including polyneuropathies) and endocrine disease including diabetes mellitus.
• No written informed consent obtained from subject.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

National University Hospital, Singapore

OTHER

Sponsor Role: lead

Other Identifiers

DSOCL08210

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

C/08/236

Identifier Type: -

Identifier Source: org_study_id