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Appetite Regulation by Human Chemosignals From Tears and Plasma

NCT ID: NCT01389869

Last Updated: 2013-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-06-30

Study Completion Date

2012-01-31

Brief Summary

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Obesity is closely related to metabolic diseases and its prevalence is sharply increasing. However, there is no safe and effective treatment for obesity so far, the investigators need a breakthrough idea to curtail the constant threat of obesity. It has been recently demonstrated that emotional tears of women can modify sexual responses, one of basic instincts, in men. As appetite and food intake is another basic instinct, chemosignals from tears and plasma may modify appetite and eating behavior in humans.

Detailed Description

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Conditions

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Obesity

Keywords

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Emotional tears Postprandial plasma Chemosignal Obesity Appetite Food intake

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Tears

Emotional tears of female volunteers while watching sad video clips

Group Type EXPERIMENTAL

Sniffing emotional tears

Intervention Type BIOLOGICAL

A band-aid soaked 100μl of emotional tears will be applied just below nostrils.

Saline

Saline collected after being trickled down women's skin below eyes like tears

Group Type PLACEBO_COMPARATOR

Sniffing trickled saline

Intervention Type BIOLOGICAL

A band-aid soaked 100μl of trickled saline will be applied just below nostrils.

Fasting

Their own overnight fasting plasma of male volunteers

Group Type PLACEBO_COMPARATOR

Sniffing fasting plasma

Intervention Type BIOLOGICAL

A band-aid soaked 100μl of own fasting plasma will be applied just below nostrils.

Prandial

Their own postprandial plasma of male volunteers

Group Type EXPERIMENTAL

Sniffing postprandial plasma

Intervention Type BIOLOGICAL

A band-aid soaked 100μl of own postprandial plasma will be applied just below nostrils.

Interventions

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Sniffing emotional tears

A band-aid soaked 100μl of emotional tears will be applied just below nostrils.

Intervention Type BIOLOGICAL

Sniffing trickled saline

A band-aid soaked 100μl of trickled saline will be applied just below nostrils.

Intervention Type BIOLOGICAL

Sniffing fasting plasma

A band-aid soaked 100μl of own fasting plasma will be applied just below nostrils.

Intervention Type BIOLOGICAL

Sniffing postprandial plasma

A band-aid soaked 100μl of own postprandial plasma will be applied just below nostrils.

Intervention Type BIOLOGICAL

Other Intervention Names

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Emotional tears Trickled saline Fasting plasma Postprandial plasma

Eligibility Criteria

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Inclusion Criteria

* Woman: Negative for HIV, Syphilis (VDRL), and Hepatitis B and C
* Man: Has a body mass index (BMI) of 18.5 kg/m2 to 27 kg/m2, inclusive.

Exclusion Criteria

* Woman: Has eyelids inflammation, conjunctivitis, keratitis, lacrimal duct obstruction. Has skin diseases around eyes.
* Man: Has diabetes mellitus or dyslipidemia on medication. Received gastrointestinal surgery except appendectomy and hemorrhoidectomy.
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Young Min Cho

Seoul National University

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Young Min Cho, MD, PHD

Role: STUDY_CHAIR

Seoul National University College of Medicine

Locations

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Seoul National University Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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H-1105-011-360

Identifier Type: -

Identifier Source: org_study_id