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The Role of Fibrocytes in Acute Lung Injury

NCT ID: NCT01373203

Last Updated: 2011-06-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-01-31

Study Completion Date

2011-12-31

Brief Summary

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The important character of acute lung injury (ALI) is alveolar capillary membrane damage caused by different diseases, such as sepsis, trauma and shock. One of the important pathological stages is the varying degrees of interstitial fibrosis and semi-permeable alveolar membrane fibrosis. It has been proved that CXCL12/SDF-1 (stromal cell-derived factor-1) induces fibrocyte migration, and promotes fibrosis progression. Study indicated that inhibition of TLR4 receptor signaling pathway improves fibrosis progression induced by ALI, however, the role of fibrocyte in ALI is still unclear. The fibrocytes was significantly increased in asthmatic patients with pulmonary fibrosis, which companies with increased CTGF expression. Therefore, this project assumes that fibrocyte will differentiation to fibroblast/myofibroblast in patient with acute lung injury, which in turn leads to progression of fibrosis. The central hypothesis of this project is that peripheral progenitor cell fibrocytes play an important role in alveolitis caused by acute lung injury. The overall objective of this project is to study the role of fibrocytes in acute lung injury.

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Detailed Description

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Conditions

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Acute Lung Injury(ALI)

Study Design

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Observational Model Type

CASE_ONLY

Eligibility Criteria

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Inclusion Criteria

* Acute Lung Injury patients
* Above 20 years old
* Bilateral lung infiltrates
* PaO2/FiO2\<300mmHg
* PCWP\<18mmHg

Exclusion Criteria

* Pregnant women
* Under 20 years old
* Hb\<8.0mg/dl
Minimum Eligible Age

20 Years

Eligible Sex

Accepts Healthy Volunteers

No

Sponsors

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Taipei Medical University WanFang Hospital

OTHER

Sponsor Role lead

Responsible Party

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Division of Pulmonary & Critical Care Medicine

Principal Investigators

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Kuan-Jen Bai

Role: PRINCIPAL_INVESTIGATOR

Taipei Medical University WanFang Hospital

Locations

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Taipei Medical University - WanFang Hospital

Taipei, , Taiwan

Site Status

Countries

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Taiwan

Other Identifiers

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99077

Identifier Type: -

Identifier Source: org_study_id

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