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Use of Procalcitonin in the Diagnosis of Pleural Effusion

NCT ID: NCT00172835

Last Updated: 2005-09-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-03-31

Brief Summary

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Among several markers of inflammation and sepsis, procalcitonin (PCT) markers is being studied to investigate their accuracy for the diagnosis of bacterial infections. PCT is the prehormone of calcitonin, which is normally secreted by the C cells of the thyroid in response to hypercalcemia; under these normal conditions, negligible serumPCT concentrations are detected. The mechanism proposed for PCT production after inflammation and its role are still not completely known. It is believed that PCT is produced by the liver and peripheral blood mononuclear cells, modulated by lipopolysaccharides and sepsis-related cytokines. It binds to polysaccharides in pathogens, activating the classical complement pathway. The reported diagnostic accuracy of PCT for the diagnosis of bacterial infections has varied across studies.

Detailed Description

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Conditions

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Pleural Effusion

Keywords

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pleural effusion procalcitonin

Study Design

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Observational Model Type

NATURAL_HISTORY

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of pleural effusion
* Pleural effusion proved by chest sonography

Exclusion Criteria

* Conditions for which thoracentesis are contraindicated
* Pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role lead

Principal Investigators

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Po-Ren Hsueh, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Laboratory Medicine, National Taiwan University Hospital

Locations

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National Taiwan University Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Po-Ren Hsueh, MD

Role: CONTACT

Phone: 886-2-2356-5363

Email: [email protected]

Facility Contacts

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Po-Ren Hsueh, MD

Role: primary

Other Identifiers

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9461700208

Identifier Type: -

Identifier Source: org_study_id