Prospective Evaluation of Patients With Pleural Effusion

NCT ID: NCT05759117

Last Updated: 2023-08-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-09-01

Study Completion Date

2026-03-31

Brief Summary

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Having a pleural effusion is a common reason for being hospitalized, as it usually requires in-patient care for invasive diagnostic and therapeutic procedures. Specific subtypes of pleural effusion may warrant recurrent admissions, a longer hospital stay and consume more healthcare resources. Despite the recent advancement of pleural medicine, better research is increasingly desired to fill the gaps in establishing an early diagnosis and optimal management of pleural effusion from various causes. Local data on different aspects of pleural effusion is also lacking.

Detailed Description

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The aetiologies of pleural effusion range from cardio-respiratory diseases, malignancy, infection to systemic inflammatory conditions. However, data on the exact incidence of individual causes of pleural effusion is inadequate. Conflicting results on the aetiologies of pleural effusion were shown in several retrospective and prospective studies based in different geographical regions, which may be explained by the different epidemiology of common diseases in the corresponding areas and patients recruited. Despite a common clinical problem, the incidence and aetiology of pleural effusion have not been examined on a population level in Hong Kong. Therefore, a local study is necessary to inform physicians about the disease burden of pleural effusion.

The management of pleural disease can be heterogeneous, as reflected by a recent multi-institutional questionnaire study in Hong Kong. Infrequent updates of international guidelines of pleural medicine, lack of an established registry reflecting the patient burden, procedure load and complications may contribute. Delayed or suboptimal management of pleural diseases can lead to unnecessary invasive procedures, prolonged hospital stays and even higher mortality rates. A local registry should be established to stocktake and understand diagnostic accuracy and complication rates of pleural procedures and reflects the real-life practice by hospital physicians.

This prospective study aims at evaluating the aetiology and management of pleural diseases prospectively. The management by the attending doctors will not be interfered. Recruited patients will be divided into subgroups based on their characteristics for further analysis. The data collected from this study will guide the planning of subsequent research to overcome the knowledge and service gap in managing pleural diseases.

Conditions

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Pleural Effusion

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Pleural effusion

All patients with pleural effusion who will undergo thoracentesis

thoracentesis

Intervention Type PROCEDURE

A type of pleural procedure that will yield pleural fluid for subsequent analysis

Interventions

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thoracentesis

A type of pleural procedure that will yield pleural fluid for subsequent analysis

Intervention Type PROCEDURE

Other Intervention Names

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chest drain insertion

Eligibility Criteria

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Inclusion Criteria

* Patients hospitalized for pleural effusion.
* Pleural tapping will be performed for pleural fluid analysis.
* Aged 18 years old or above

Exclusion Criteria

\- Failed to obtain informed consent due to the patient's refusal or cognitive impairment
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chinese University of Hong Kong

OTHER

Sponsor Role lead

Responsible Party

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Ka Pang Chan

Clinical Lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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David SC Hui, MD

Role: STUDY_DIRECTOR

Chinese University of Hong Kong

Locations

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Chinese University of Hong Kong

Hong Kong, , Hong Kong

Site Status RECRUITING

Prince of Wales Hospital

Hong Kong, , Hong Kong

Site Status RECRUITING

Countries

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Hong Kong

Central Contacts

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Ka Pang Chan, MBChB

Role: CONTACT

Facility Contacts

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Ka Pang Chan, MBChB

Role: primary

852 3505 3396

David SC Hui, MD

Role: backup

852 2632 3128

Ka Pang Chan, MBChB

Role: primary

852 3505 3396

David SC Hui, MD

Role: backup

852 2632 3128

Other Identifiers

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ProspectivePleuralEffusion

Identifier Type: -

Identifier Source: org_study_id

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