COX-2 Inhibitor Versus Glucocorticoid Versus Both Combined

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

93 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-01-31

Study Completion Date

2009-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Recent studies on molar surgery have shown that a combination of a glucocorticoid and NSAID or COX-2 selective inhibitor gives better pain relief than either of the drugs used separately. The investigators group has also shown that adding dexamethasone on top of a regimen of paracetamol, NSAID and local anesthesia resulted in 45% painfree patients at rest after ambulatory breast cancer surgery.

The goal of this study is to test the NSAID + glucocorticoid concept in ACl repair. The investigators want to evaluate whether a selective COX-2 selective inhibitor or a glucocorticoid or a combination of both drugs, as part of a multimodal analgesic regime, can provide improved pain relief and shorter hospital stay in patients undergoing outpatient ACL surgery.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen on Postoperative Pain After Spine Surgery

NCT01953978

Pain

COMPLETED PHASE4

Effect of Combinations of Paracetamol, Ibuprofen, and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty

NCT04123873

Pain, Acute Hip Arthropathy Analgesia +1 more

COMPLETED PHASE4

Effect of Paracetamol, Pregabalin and Dexamethasone on Pain and Opioid Requirements in Patients After Hip Operations

NCT00235261

Pain Postoperative

COMPLETED PHASE4

Effect of Paracetamol,Pregabalin and Dexamethasone on Pain and Opioid Requirements in Postoperative Patients

NCT00209495

Pain, Postoperative

COMPLETED PHASE4

Postoperative Pain, Why Still in Hospital and DAOH Following TORS for SCCUP & OSAS

NCT04189107

Analgesia Surgery Cancer of Head and Neck +4 more

COMPLETED PHASE3

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Rupture of Anterior Cruciate Ligament

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

COXIB

40 mg parecoxib (Dynastat, Pfizer®) one hour before surgery and 40 mg valdecoxib (prodrug of parecoxib, Bextra, Pfizer®)were given 8 hour after surgery.

After retraction of parecoxib from the market:

Etoricoxib (Arcoxia, MSD) 120 mg given one hour before surgery

Group Type ACTIVE_COMPARATOR

parecoxib, valdecoxib, etoricoxib

Intervention Type DRUG

40 mg parecoxib (Dynastat, Pfizer®) one hour before surgery and 40 mg valdecoxib (prodrug of parecoxib, Bextra, Pfizer®)were given 8 hour after surgery.

After retraction of parecoxib from the market:

Etoricoxib (Arcoxia, MSD) 120 mg given one hour before surgery

Dexamethasone

dexamethasone 8 mg iv

Group Type ACTIVE_COMPARATOR

Dexamethasone

Intervention Type DRUG

8 mg IV

COXIB and dexamethasone

combination of coxib AND dexamethasone

Group Type ACTIVE_COMPARATOR

parecoxib, valdecoxib, parecoxib and dexamethasone

Intervention Type DRUG

combination of both drugs

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

parecoxib, valdecoxib, etoricoxib

40 mg parecoxib (Dynastat, Pfizer®) one hour before surgery and 40 mg valdecoxib (prodrug of parecoxib, Bextra, Pfizer®)were given 8 hour after surgery.

After retraction of parecoxib from the market:

Etoricoxib (Arcoxia, MSD) 120 mg given one hour before surgery

Intervention Type DRUG