Pre-Emptive Analgesia Efficacy of Etoricoxib for Postoperative Pain

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-12-31

Study Completion Date

2005-05-31

Brief Summary

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Taken together, studies of the value of pre-emptive analgesia are inconclusive. This randomized, double-blind, dose-ranging, placebo-controlled study was therefore designed to test that a reduction in post-operative morphine consumption can be achieved by a single-dose of etoricoxib before induction of anesthesia.

Detailed Description

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Patients undergoing transabdominal hysterectomy were randomized to a group taking a single dose (orally) of etoricoxib 120 mg (n = 18), etoricoxib 180 mg (n = 17) or placebo (n = 15) 2 hours before surgery under the same standardized general anesthesia. At the post-anesthetic care unit, intravenous morphine titration was given before starting self-controlled analgesia (PCA) device. Morphine consumption, pain relief score, sedative score, global evaluation score, and side-effects were recorded at 1, 2, 4, 8 and 24 h post-operatively. The primary end points were morphine consumption within 24-hr post-operatively and total pain relief over 8 h (TOPAR8). Patient global satisfaction was also assessed.

Conditions

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a Single-Dose of Etoricoxib Post-Operative Morphine Consumption Total Pain Relief Over 8 Hr(TOPAR8) Post Transabdominal Hysterectomy

Keywords

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Abdominal hysterectomy, Etoricoxib, morphine consumption, pre-emptive analgesia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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a single-dose of Etoricoxib before induction of anesthesia

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* The ASA I or II patients undergoing elective transabdominal hysterectomy with general anesthesia

Exclusion Criteria

* Patients with history of opioid addiction or chronic pain
* Allergy to other nonsteroidal anti-inflammatory, or asthma
* Concomitant use of tricyclic antidepressants, opioid analgesics, antihistamines, tranquilizers, hypnotics, sedatives, or systemic corticosteroids
* Those unable to understand the principle of patient-controlled analgesia(PCA) device were excluded from the study

Minimum Eligible Age

15 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Principal Investigators

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waraporn chau-in, Asso Prof.

Role: PRINCIPAL_INVESTIGATOR

Department of Anesthesiology, Faculty of Medicine,KhonKaen University,KhonKaen 40002, Thailand

Locations

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Warporn Chau-in

KhonKaen University, KhonKaen, Thailand

Site Status

Countries

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Thailand

Other Identifiers

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Faculty of Medicine,KhonKaenU

Identifier Type: -

Identifier Source: secondary_id

acute pain service