Vascular and Periodontal Disease - Microbial, Genetic and Histological Causalities

NCT ID: NCT01358630

Last Updated: 2011-05-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-10-31

Study Completion Date

2015-10-31

Brief Summary

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The purpose of this study is to analyze genetic polymorphisms in genes encoding pro-inflammatory cytokines, and study the genetic predisposition to chronic periodontitis (CP) in combination with atherosclerotic cardiovascular (ACD) and aneurysmal diseases. The investigators will also try to identify oral bacteria in atherosclerotic plaques and aneurysmal walls and thrombus. Histological analyses of atherosclerotic plaques and aneurysmal wall will be performed.

Detailed Description

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Conditions

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Periodontitis Vascular Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis,

Exclusion Criteria

* patients whom undergone antibiotic treatment the past month.
* patients whom undergone periodontal treatment the past 6 months.
* patients with no teeth
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Oslo University Hospital

OTHER

Sponsor Role collaborator

University of Oslo

OTHER

Sponsor Role lead

Responsible Party

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Institute of Oral Biology, Dental Faculty, University of Oslo/Oslo University Hospital, Departemnt of vascular surgery

Locations

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Dental and Medical Faculty, University of Oslo

Oslo, Oslo County, Norway

Site Status RECRUITING

Countries

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Norway

Central Contacts

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Ingar Olsen, Prof.PhD.

Role: CONTACT

+47-22840350

Jørgen J Jørgensen, Prof.PhD

Role: CONTACT

+47-22894496

Facility Contacts

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Ingar Olsen, Prof.PhD

Role: primary

47 22 84 03 50

Jørgensen J Jørgensen, Prof.PhD

Role: backup

47 22 89 44 96

Other Identifiers

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08/322b

Identifier Type: -

Identifier Source: org_study_id

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