The Association Between Different Monocyte Subsets and Coronary Collateral Development
NCT ID: NCT01356836
Last Updated: 2011-05-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
105 participants
OBSERVATIONAL
2011-01-31
2011-05-31
Brief Summary
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However, coronary collateral development is different among patients even with similar degrees of coronary artery stenosis. Several factors, such as diabetes mellitus (4) and duration of myocardial ischemic symptoms (5) have been reported to effect coronary collateral development. At the cellular level, inflammatory cells, especially monocytes have an important role in collateralization. In a series of experimental studies with animals, it has been shown that monocytes are important elements for development of collateral vessels (6-7). In a recent study, it has been demonstrated that increased circulating monocyte count is related to good collateral development in patients with stable coronary artery disease (8).
Monocytes in human blood are heterogeneous and can be classified into two subsets according to the presence or absence of the FcγRIII receptor CD16 (9): CD14++CD16- monocytes characterized by high level expression of the CD14 cell surface receptor but no expression of CD16 receptor, and CD14+CD16+ monocytes characterized by the co-expression of CD16 receptor with either high or low level expression of the CD14 receptor. These subsets differ in function and response to several cytokines.
Our aim in this study was to find out any possible relationship between the levels of circulating monocyte subsets and coronary collateral development.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Good-poor collateral
Patients who had good and poor collaterals formed 2 groups
No interventions assigned to this group
Good collateral, Poor collateral
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* evidence of ongoing infection and inflammation
* known malignancy and chronic kidney disease (serum creatinine \> 1.5 mg/dl
* diabetic patients
18 Years
80 Years
ALL
No
Sponsors
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Yuksek Ihtisas Hospital
OTHER
Responsible Party
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Specialist of Cardiology
Locations
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1Türkiye Yüksek İhtisas Education and Research Hospital, Department of Cardiology
Ankara, , Turkey (Türkiye)
Countries
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Other Identifiers
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Monocyte subsets
Identifier Type: -
Identifier Source: org_study_id
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