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Influence of Extracorporeal Circulation on Platelet Function of Patients Undergoing Cardiac Surgery

NCT ID: NCT01354847

Last Updated: 2013-10-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

25 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-06-30

Study Completion Date

2013-10-31

Brief Summary

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This study is planned to investigate the relationship between duration of extracorporeal circulation and the extent of (acquired) platelet dysfunctions in patients undergoing cardiac surgery.

Detailed Description

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Patients undergoing complex cardiac surgery are planned to be included. At several intra- and postoperative measuring point, blood is drawn for multiple electrode aggregometry to investigate ex-vivo platelet aggregation as a surrogate for platelet function.

Transfusion rate of allogenic blood products as well as postoperative blood loss is planned to be recorded.

Conditions

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Acquired Platelet Function Disorder

Keywords

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extracorporeal circulation platelet dysfunction Multiplate electrode aggregometry analyses Multiplate

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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cardiac surgery patients

cardiac surgery patients scheduled for elective complex cardiac surgery

Multiple electrode aggregometry analyses (Multiple Electrode Aggregometry, Multiplate(R), Verum Diagnostica, Munich, Germany)

Intervention Type DEVICE

ex vivo platelet aggregation at several intraoperative and postoperative measuring points.

Interventions

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Multiple electrode aggregometry analyses (Multiple Electrode Aggregometry, Multiplate(R), Verum Diagnostica, Munich, Germany)

ex vivo platelet aggregation at several intraoperative and postoperative measuring points.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* duration of extracorporeal circulation \> 120 min

Exclusion Criteria

* pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Goethe University

OTHER

Sponsor Role lead

Responsible Party

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Christian F. Weber, MD

Dr. Dr. Christian Friedrich Weber

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Christian F Weber, M.D.

Role: PRINCIPAL_INVESTIGATOR

Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany

Christian Reyher, M.D.

Role: STUDY_CHAIR

Goethe University Frankfurt, Clinic for Anesthesiology, Theodor Stern Kai 7, 60590 Frankfurt, Germany

Locations

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Goethe - University

Frankfurt am Main, Hesse, Germany

Site Status

Countries

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Germany

References

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Velik-Salchner C, Maier S, Innerhofer P, Kolbitsch C, Streif W, Mittermayr M, Praxmarer M, Fries D. An assessment of cardiopulmonary bypass-induced changes in platelet function using whole blood and classical light transmission aggregometry: the results of a pilot study. Anesth Analg. 2009 Jun;108(6):1747-54. doi: 10.1213/ane.0b013e3181a198ac.

Reference Type BACKGROUND
PMID: 19448196 (View on PubMed)

Other Identifiers

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MEAECC

Identifier Type: -

Identifier Source: org_study_id