Effect of Epidural Anesthesia on Blood Flow in Arterial Anastomosis of Free Flap
NCT ID: NCT03330808
Last Updated: 2020-05-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
52 participants
INTERVENTIONAL
2017-10-28
2020-05-05
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
QUADRUPLE
Study Groups
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Epidural with general anesthesia
Epidural anesthesia with 0.2% ropivacaine 10 ml
Epidural anesthesia
After anesthesia induction, epidural catheter is inserted into lumbar epidural in epidural with general anesthesia group. A 10 ml of 0.2% ropivacaine should be given in epidural space via a catheter when anastomosis of free flap is finished in epidural with general anesthesia group.
General anesthesia alone
Sevoflurane and nitrous oxide.
No interventions assigned to this group
Interventions
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Epidural anesthesia
After anesthesia induction, epidural catheter is inserted into lumbar epidural in epidural with general anesthesia group. A 10 ml of 0.2% ropivacaine should be given in epidural space via a catheter when anastomosis of free flap is finished in epidural with general anesthesia group.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* 18 years of age or older, under 80 years of age
* Those who voluntarily agreed to participate in this clinical study
Exclusion Criteria
* ASA physical status IV or higher
* If the patient was diagnosed with diabetes
* If the patient was diagnosed with chronic renal failure
* If the patient was diagnosed with peripheral vascular disease or hyperlipidemia
* If vasopressors or inotropics was used preoperatively.
* Contraindication of epidural anesthesia such as usage of anticoagulant or abnormalities of laboratory finding.
* If the researcher finds it to be inappropriate
18 Years
79 Years
ALL
No
Sponsors
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Asan Medical Center
OTHER
Responsible Party
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Young-Kug Kim
Principal Investigator
Principal Investigators
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Young-Kug Kim, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Asan Medical Center
Locations
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Asan Medical Center
Seoul, , South Korea
Countries
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References
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Wright CJ, Cousins MJ. Blood flow distribution in the human leg following epidural sympathetic blockade. Arch Surg. 1972 Aug;105(2):334-7. doi: 10.1001/archsurg.1972.04180080180030. No abstract available.
Tuman KJ, McCarthy RJ, March RJ, DeLaria GA, Patel RV, Ivankovich AD. Effects of epidural anesthesia and analgesia on coagulation and outcome after major vascular surgery. Anesth Analg. 1991 Dec;73(6):696-704. doi: 10.1213/00000539-199112000-00005.
Pallares LC, Deane CR, Baudouin SV, Evans TW. Strain gauge plethysmography and Doppler ultrasound in the measurement of limb blood flow. Eur J Clin Invest. 1994 Apr;24(4):279-86. doi: 10.1111/j.1365-2362.1994.tb01086.x.
Lou F, Sun Z, Huang N, Hu Z, Cao A, Shen Z, Shao Z, Yu P, Miao C, Wu J. Epidural Combined with General Anesthesia versus General Anesthesia Alone in Patients Undergoing Free Flap Breast Reconstruction. Plast Reconstr Surg. 2016 Mar;137(3):502e-509e. doi: 10.1097/01.prs.0000479933.75887.82.
Delis KT, Knaggs AL, Mason P, Macleod KG. Effects of epidural-and-general anesthesia combined versus general anesthesia alone on the venous hemodynamics of the lower limb. A randomized study. Thromb Haemost. 2004 Nov;92(5):1003-11. doi: 10.1160/TH04-04-0233.
Other Identifiers
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2017-1200
Identifier Type: -
Identifier Source: org_study_id
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