Evaluation of the Microcirculation During the Corrective Surgery of Congenital Heart Defects in Children
NCT ID: NCT03144258
Last Updated: 2019-08-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
100 participants
OBSERVATIONAL
2018-02-20
2018-12-30
Brief Summary
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Detailed Description
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* To test the usefulness of skin laser Doppler flowmetry monitoring (LDPM) in the non-invasive evaluation of endothelium-dependent microvascular reactivity during CPB in children.
* To investigate whether skin LDPM could be proposed as a clinical monitoring of tissue perfusion during CPB in pediatric cardiac surgery.
* To investigate the effects of different anesthetic agents on microvascular reactivity during CPB.
* To investigate the effects of cardiovascular and vasoactive drugs used during CPB on microvascular reactivity.
* To evaluate the correlation of microcirculatory alterations observed during CPB with classical markers of tissue perfusion and oxygenation, including plasma lactate levels.
* To evaluate the correlation of microcirculatory alterations observed during CPB with markers of systemic inflammation, including pro- and anti-inflammatory cytokines.
* To evaluate the correlation of microcirculatory alterations observed during CPB with the plasma bioavailability of nitric oxide.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
3 Months
6 Years
ALL
No
Sponsors
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National Institute of Cardiology, Laranjeiras, Brazil
OTHER_GOV
Responsible Party
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Eduardo Tibirica, MD, PhD
Senior Researcher
Principal Investigators
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Eduardo Tibirica, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
National Institute of Cardiology
Locations
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National Institute of Cardiology, Ministry of Health, Brazil
Rio de Janeiro, , Brazil
Countries
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Other Identifiers
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CAAE 19201413.6.0000.5272
Identifier Type: -
Identifier Source: org_study_id
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