Acute Cardiovascular Effects of Cigarette Smoking

NCT ID: NCT01346956

Last Updated: 2011-05-04

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 20 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2002-07-31
• Study Completion Date: 2002-08-31

Brief Summary

Twenty healthy smokers will be subjected to measurement of Pulse, Blood Pressure, electrocardiogram (ECG) and Echo at baseline and after smoking a cigarette. The measurements will be compare for any cardiovascular effects of a cigarette smoking on these parameters.

Detailed Description

Twenty male persons habituated to smoking (at least 5 cigarettes/day) will be recruited after an informed consent. Healthy persons with no systemic illness will be included. After a history and a routine examination, subjects will be asked to abstain from smoking for 3 hours and then their pulse, BP, ECG and echo recorded. The measurements will be repeated after 15 min. and the average of these two taken as baseline readings. Then, they will be asked to smoke a cigarette and the measurements taken again. Special focus will be on Doppler measures of left ventricular (LV) function. The measurements are repeated immediately and at 5,10 and 15 min. The data will be analyzed for any cardiovascular effects of smoking a cigarette. Chi square test for proportions and t-test for means will be done. A p value < 0.05 will be taken as significant.

Conditions

Smoking

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Healthy male smokers (at least 5 cigarettes /day) >18 years old.

Exclusion Criteria

• Any cardiac or respiratory or systemic illness,including hypertension.

• Minimum Eligible Age: 18 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Andhra Medical College

OTHER_GOV

Sponsor Role: lead

Responsible Party

Andhra Medical College

Principal Investigators

Venkatachelam R Chitrapu, MD DM

Role: PRINCIPAL_INVESTIGATOR

Andhra Medical College

Locations

Andhra Medical College

Visakhapatnam, Andhra Pradesh, India

Countries

India

Other Identifiers

02AMCRAVSAND07

Identifier Type: -

Identifier Source: org_study_id