Subclassification of the Syndrome of Inappropriate ADH Secretion

NCT ID: NCT01341665

Last Updated: 2011-04-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-03-31

Study Completion Date

2011-04-30

Brief Summary

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The aim of this study is to evaluate the different types of osmotic dysregulation in patients with Syndrome of Inappropriate ADH (SIADH) and, hence, to analyze the pathophysiology of SIADH.

These types will be characterized by measurement of AVP and copeptin while performing an osmotic stimulation with infusion of hypertonic saline.

Detailed Description

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Conditions

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Hyponatremia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* age \> 18 years,
* hyponatremia \< 132 mmol/L
* SIADH

Exclusion Criteria

* age \< 18 years
* cerebral metastases
* serum sodium \> 132mmol/L
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Wuerzburg

OTHER

Sponsor Role lead

Responsible Party

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Department of Endocrinology and Diabetes, University of Wuerzburg

Principal Investigators

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Bruno Allolio, MD

Role: STUDY_CHAIR

Ethical commitee

Locations

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University of Wuerzburg

Würzburg, Bavaria, Germany

Site Status

Countries

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Germany

Other Identifiers

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5/08

Identifier Type: -

Identifier Source: org_study_id

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