Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

14 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-03-31

Study Completion Date

2011-01-31

Brief Summary

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During infections (sepsis) bloodflow in small vessels (microcirculation) becomes disturbed. Restoration of bloodpressure and cardiac performance may not be sufficient to correct these alterations. Magnesium is a potent vasodilator which may be used to open up the small vessels, in order to reduce organ failure.

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Detailed Description

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In a single-center open label study we evaluated the effects of magnesium sulphate (MgS) infusion on the sublingual microcirculation perfusion in fluid resuscitated patients with severe sepsis and septic shock within the first 48 hours after ICU admission. Directly prior to and after 1 hour of magnesium sulphate (MgS) infusion (2 gram) systemic hemodynamic variables, sublingual SDF images and standard laboratory tests, were obtained.

Conditions

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Severe Sepsis Septic Shock

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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severe sepsis and septic shock

Magnesium Sulfate

Intervention Type DRUG

2 gram in 1 hour

Interventions

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Magnesium Sulfate

2 gram in 1 hour

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* severe sepsis and septic shock

Exclusion Criteria

* pregnancy
* oral bleeding
* age \< 18 years
* liver cirrhosis
* acute arrhythmias
* advanced malignancy or a mean arterial pressure (MAP) \< 65 mmHg refractory to vasopressors

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No