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Vasopressor Use Improves Macrocirculation, But What Are Its Effects on Microcirculation?

NCT ID: NCT07312071

Last Updated: 2025-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-04-01

Study Completion Date

2023-09-30

Brief Summary

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To manage the treatment in the intensive care unit for patients with septic shock, central venous oxygen saturation (scvO2) is used as a macrocirculatory indicator, with a target value of 70% or higher being recommended. Tissue oxygenation (stO2) measurement can be implemented to assess the microcirculation in these patients, but a specific target value has not been established yet. The investigators believe that guiding the treatment of septic shock patients based on the measurement of microcirculation using stO2 and evaluating its correlation with scvO2 can reduce mortality.

This study aims to investigate the independent impact of high-dose norepinephrine on microvascular reactivity assessed by NIRS-VOT in patients with septic shock, while also examining how these microcirculatory indices relate to the macrocirculatory marker ScvO₂.

Detailed Description

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Conditions

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Septic Shock Sepsis Tissue Ischemia Hemodynamic Instability

Keywords

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Tissue oxygenation Vazopressor Septic Shock Sepsis microcirculation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Study group

The study will include adult patients aged 18 and above who are receiving vasopressor therapy due to septic shock in the intensive care unit.

Group Type OTHER

Vascular Occlusion Test

Intervention Type DIAGNOSTIC_TEST

The vascular occlusion test is a procedure performed to assess the vascular status and perfusion of a limb. It involves temporarily stopping blood flow to the limb by applying a blood pressure cuff.

Interventions

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Vascular Occlusion Test

The vascular occlusion test is a procedure performed to assess the vascular status and perfusion of a limb. It involves temporarily stopping blood flow to the limb by applying a blood pressure cuff.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Age 18 years or older
* Diagnosis of septic shock
* Receiving vasopressor and mechanical ventilation therapy
* Presence of a central venous catheter that allows ScvO₂ sampling
* Ability to obtain tissue oxygenation (stO₂) measurements using a NIRS probe placed on the thenar eminence
* Written informed consent obtained from patient or legal representative

Exclusion Criteria

* Local infection, wound, or skin lesion at the planned NIRS probe application site
* Mean arterial pressure (MAP) \< 60 mmHg despite vasopressor therapy
* Pregnancy
* Inability to safely perform the vascular occlusion test (as judged by treating clinician)
* Any condition preventing safe blood sampling or reliable stO₂ measurement
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Gaziosmanpasa Research and Education Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Oguz Özakın

Anesthesiology and Reanimation Specialist

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Gaziosmanpasa Training Research Hospital

Istanbul, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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1234

Identifier Type: -

Identifier Source: org_study_id