Subclinical Atherosclerosis Using Dual-source CT Coronary Angiography in Chinese Adults With Different Glycaemic Status
NCT ID: NCT01319201
Last Updated: 2011-03-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
600 participants
OBSERVATIONAL
2010-04-30
Brief Summary
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Aims:
To evaluate coronary artery calcification and stenosis in community-dwelling adults with different glycaemic status, using dual-source CT angiography (CTA)
Study Subjects and Methods:
200 adults with normal glucose regulation (NGR), 200 with impaired glucose regulation (IGR) and 200 with type 2 diabetes were recruited from an urban community of Shanghai, who then underwent a comprehensive examination including questionnaire, anthropometric measurements, biochemical analysis and CTA.
Part II: Follow-up of Cardiovascular Events and Re-evaluation of Coronary Artery Calcification and Stenosis
Aims and Methods:
To investigate the development of cardiovascular diseases in subjects recruited in part I and re-evaluate coronary artery calcification and stenosis using CTA after 3-year follow-up
To identify the predictive value of coronary artery calcification and stenosis with future risks of cardiovascular diseases and the possible development of coronary artery disorders among participants with different glycaemic status
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Impaired glucose regulation
This group of subjects was diagnosed as impaired glucose regulation using oral glucose tolerance test.
No interventions assigned to this group
Type 2 diabetes
This group of subjects was diagnosed as type 2 diabetes using oral glucose tolerance test.
No interventions assigned to this group
Normal glucose regulation
This group of subjects was considered normal regarding glucose metabolism using oral glucose tolerance test.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
2. Gender: males and females
3. Provide written informed consent
4. Satisfactory compliance
Exclusion Criteria
2. Allergy to iodine
3. Exposure to radiation within last 3 months
4. ALT more than 100IU/L, or serum creatine more than 133μmol/l \[1.5mg/dl\] or GFR less than 60ml/min
5. Heart rate more than 100 bpm or severe arrhythmia
6. Malignancy, myocardial infection, acute hepatitis or other major diseases
40 Years
70 Years
ALL
No
Sponsors
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Shanghai Jiao Tong University School of Medicine
OTHER
Responsible Party
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Shanghai Jiao-Tong University School of Medicine
Principal Investigators
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Guang Ning, M.D.; PH.D.
Role: PRINCIPAL_INVESTIGATOR
Shanghai Jiao Tong University School of Medicine
Locations
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Shanghai Jiao-Tong University School of Medicine
Shanghai, , China
Countries
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Other Identifiers
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CCEMD009
Identifier Type: -
Identifier Source: org_study_id
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