The Imaging Genetic Study of Type 2 Diabetes and Depression

NCT ID: NCT03564431

Last Updated: 2019-09-17

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 120 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-12-01
• Study Completion Date: 2020-12-01

Brief Summary

To investigate the structural/functional abnormalities and the possible genetic endophenotypes of in the Type 2 Diabetes Patient With Depression.

Detailed Description

Diabetes and depression are harmful to human health,but they often co-exist.At present, the pathophysiological mechanisms underlying the comorbidity of diabetes and depression are discussed, including hypothalamic-pituitary-adrenal axis dysfunction, inflammation, epigenetics, disturbed circadian rhythms, environmental and behavioral factors,neuroimaging,etc.the purpose of the investigator's study is to investigate the structural/functional abnormalities and the possible genetic endophenotypes of in the Type 2 Diabetes Patient With Depression.

Conditions

T2DM

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

controls

Magnetic resonance

Intervention Type: DEVICE

magnetic resonance spectrum of brain

T2DM patients

Magnetic resonance

Intervention Type: DEVICE

magnetic resonance spectrum of brain

depression patients

Magnetic resonance

Intervention Type: DEVICE

magnetic resonance spectrum of brain

T2DM with depression patients

Magnetic resonance

Intervention Type: DEVICE

magnetic resonance spectrum of brain

Interventions

Magnetic resonance

magnetic resonance spectrum of brain

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

conform to type 2 diabetes, depression, diagnostic criteria of unrelated normal controls the han nationality patients; Aged 30 to 70 years of age, gender not limited; The patient or legal guardian have signed informed consent of patients.

Exclusion Criteria

Magnetic resonance imaging has the contraindication, such as metal implants, claustrophobic, etc.

With severe body diseases, including inflammatory diseases and autoimmune diseases; Current or past history of nervous system disease or brain injury. Merge other severe mental illness or existing psychotic symptoms; Always have a mania, hypomania attack; Has a history of substance abuse; Pregnant women and nursing mothers; Estimated compliance is poorer, not partners; Is being treated for a mental drug therapy, and ECT, TMS; Patients with a body mass index > 35; There are currently no taking corticosteroids, immune regulator, etc. Now or ever did not suffer from patients with other diagnosis to the dsm-iv axis I; Merge the endocrine system disease, thyroid, adrenal gland and pituitary gland diseases, etc.

• Minimum Eligible Age: 30 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Kunming Medical University

OTHER

Sponsor Role: lead

Responsible Party

Yuqi Cheng

associate professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Xiufeng Xu, MD

Role: PRINCIPAL_INVESTIGATOR

Psychiatry department of KMU

Locations

Psychiatry department, The 1st Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, China

Site Status: RECRUITING

Countries

China

Central Contacts

Li Shi, MD

Role: CONTACT

shili1026@163.com.cn

8687165324888

Facility Contacts

Xiufeng Xu, MD

Role: primary

xfxu2004@sina.com

8687165324888

References

Cui F, Ouyang ZQ, Zeng YZ, Ling BB, Shi L, Zhu Y, Gu HY, Jiang WL, Zhou T, Sun XJ, Han D, Lu Y. Effects of hypertension on subcortical nucleus morphological alternations in patients with type 2 diabetes. Front Endocrinol (Lausanne). 2023 Sep 13;14:1201281. doi: 10.3389/fendo.2023.1201281. eCollection 2023.

Reference Type: DERIVED

PMID: 37780620 (View on PubMed)

Other Identifiers

841026

Identifier Type: -

Identifier Source: org_study_id